A New Strategy to Uncover the Anticancer Mechanism of Chinese Compound Formula by Integrating Systems Pharmacology and Bioinformatics

Figure 4

The genetic alterations and survival analysis related to 7 overlapping targets (including CDK2, CDKN1A, MDM2, CCND1, TP53, CCNE1, and CCNE2) in PCa studies embedded in cBio cancer genomics Portal. (a) Overview of changes in 7 overlapping targets in genomics datasets available in 13 different PCa studies. (b) OncoPrint: a visual summary of alterations across a set of prostate samples (data taken from the Michigan studies, Nature 2012) [10] based on a query of the 7 overlapping targets. Distinct genomic alterations including mutations and copy number alterations (CNAs, exemplified by gene amplifications and homozygous deletions) were summarized, and the color codes represented % changes) in particular targets in individual cancer samples. Each row stood for a gene, and each column represented a cancer sample. Red bars stood for gene amplifications, blue bars represented homozygous deletions, and green squares indicated nonsynonymous mutations. (c) K-M curve between groups with alterations and without alterations. Red line represented cases with alterations, and the blue one indicated cases without. The X-axis was overall survival (OS, months), and the Y-axis stood for the survival rate. Kaplan-Meier test was performed.

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