Abyssinone V-4’ Methyl Ether Isolated from Erythrina droogmansiana (Leguminosae) Inhibits Cell Growth and Mammary Glands Hyperplasia Induced in Swiss Mice by the 7,12-Dimethylbenz(a)anthracene

Figure 3

Effects of Abyssinone V-4’ methyl ether on microphotographs H&E 400× of mammary glands (a), uterine (b), and graphic representation of uterine epithelial height (c) after 28 days of treatment. NOR = normal mice treated with distilled water; DMBA = negative control treated with water; DMBA + AVME 10 = animals treated with the Abyssinone V-4’ methyl ether at the dose of 10 mg/kg. All groups except the normal group (control) received an intragastric dose of DMBA at the dose of 100 mg/kg. Data are represented as mean ± SD (n = 5). At = adipose tissue; Se = eosinophil secretion, L = lobular; HLU = hyperplastic lobular unit; St = stroma, Lu = lumen of uterus, Ge = germinal epithelium, En = endometrium, and Ct = conjunctive tissue.

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