Abyssinone V-4’ Methyl Ether Isolated from Erythrina droogmansiana (Leguminosae) Inhibits Cell Growth and Mammary Glands Hyperplasia Induced in Swiss Mice by the 7,12-Dimethylbenz(a)anthracene

Table 2

Breast cancer chemopreventive activity of Abyssinone V-4’ methyl ether after 28 days of treatment.

Items	Control	DMBA	DMBA + AVME 10
Number of mice with tumours/total rats	0/6	3/5	1/5
Localized tumor incidence (%)	0	60	20
Average tumor weight (g/kg)	-	1.04 ± 03.4	0.48 ± 0.92
% Inhibition related to tumor weight	-	-	53.84
Total tumor burden (g)	0	3.92	1.67
% Inhibition related to tumor burden	-	-	57.39
Volume (cm^3)	-	15.32 ± 3.01	6.8 ± 0.5

NOR = normal mice treated with distilled water; DMBA = negative control treated with water; DMBA + AVME 10 = animals treated with the Abyssinone V-4’ methyl etherat the dose of 10 mg/kg. All groups except the normal group (control) received an intragastric dose of DMBA at the dose of 100 mg/kg. Data are represented as mean ± SD (n = 5). p < 0.01 and p < 0.001 as compared to negative control; < 0.001 as compared to normal group.