Abyssinone V-4’ Methyl Ether Isolated from Erythrina droogmansiana (Leguminosae) Inhibits Cell Growth and Mammary Glands Hyperplasia Induced in Swiss Mice by the 7,12-Dimethylbenz(a)anthracene

Table 4

Effects of Abyssinone V-4’ methyl etheron some biochemical and hematological parameters following 28 days of treatment.

Item	Control	DMBA	DMBA + AVME 10
Biochemical parameters
AST	37.2 ± 1.26	42.6 ± 2.13	28.6 ± 1.78
Creatinine (g/L)	0.8 ± 0.06	1.3 ± 0.10	0.36 ± 0.08
Hematological parameters
WBC (×10^3µL^−1)	7.42 ± 2.67	7.4 ± 2.48	8.7 ± 0.72
Lymphocytes (%)	61.1 ± 4.32	57.11 ± 4.91	64.5 ± 5.69
Monocytes (%)	11.4 ± 3.3	11.2 ± 0.04	12.67 ± 2.08
Granulocytes (%)	25.1 ± 5.5	32.1 ± 4.59	23.23 ± 4.28
Hemoglobin	171.1 ± 6.99	138.2 ± 9.35	151.66 ± 16.17
RBC (×10^3µL^−1)	9.2 ± 0.051	8.48 ± 0.35	9.13 ± 1.08
Platelets (×10^3µL^−1)	453 ± 10.42	959.2 ± 11.07	833.33 ± 294.65

Control = normal mice treated with distilled water; DMBA = negative control treated with distilled water; DMBA + AVME 10 = animals treated with the Abyssinone V-4’ methyl etherat the dose of 10 mg/kg. All groups except the normal group (control) received an intragastric dose of DMBA at the dose of 100 mg/kg. Data are represented as mean ± SD (n = 5). p < 0.05. p < 0.01 as compared to negative control; < 0.05 and < 0.01 as compared to normal group.