Research Article
The Variant at TGFBRAP1 but Not TGFBR2 Is Associated with Antituberculosis Drug-Induced Liver Injury
Table 3
Genetic models of related SNPs associated with ATDILI in tuberculosis patients.
| Gene | dbSNP | Dominant model | Recessive model | Additive model | OR (95% CI) | | OR (95% CI) | | OR (95% CI) | |
| TGFBRAP1 | rs17687727 | 1.634 (1.076–1.634) | 0.021 | 1.982 (0.620–6.335) | 0.248 | 1.559 (1.083–2.246) | 0.017 | rs75725426 | 1.073 (0.661–1.073) | 0.774 | 0.900 (0.198–4.078) | 0.891 | 1.047 (0.684–1.601) | 0.832 | rs2241797 | 1.064 (0.716–1.064) | 0.759 | 0.845 (0.390–1.833) | 0.670 | 1.010 (0.740–1.377) | 0.951 | rs2576736 | 0.793 (0.526–0.793) | 0.268 | 0.908 (0.397–2.076) | 0.819 | 0.847 (0.607–1.182) | 0.329 | rs12476720 | 0.873 (0.562–0.873) | 0.546 | 0.965 (0.608–1.532) | 0.882 | 0.936 (0.708–1.237) | 0.643 | rs2679876 | 0.816 (0.537–0.816) | 0.342 | 0.632 (0.219–1.820) | 0.395 | 0.820 (0.576–1.168) | 0.272 |
| TGFBR2 | rs1835538 | 0.762 (0.479–1.211) | 0.250 | 0.885 (0.195–4.007) | 0.874 | 0.792 (0.519–1.209) | 0.280 | rs9881945 | 1.078 (0.694–1.673) | 0.737 | 1.142 (0.323–4.038) | 0.836 | 1.073 (0.729–1.578) | 0.720 | rs4522809 | 1.071 (0.722–1.589) | 0.733 | 0.513 (0.216–1.219) | 0.131 | 0.937 (0.688–1.276) | 0.682 | rs11924422 | 0.922 (0.622–1.367) | 0.685 | 0.911 (0.436–1.904) | 0.805 | 0.934 (0.683–1.278) | 0.670 | rs12493607 | 1.052 (0.707–1.565) | 0.800 | 0.885 (0.452–1.734) | 0.723 | 1.004 (0.743–1.356) | 0.978 | rs1808602 | 0.964 (0.626–1.484) | 0.869 | 0.732 (0.432–1.241) | 0.246 | 0.893 (0.672–1.188) | 0.437 | rs1078985 | 0.959 (0.619–1.487) | 0.854 | 1.583 (0.572–4.376) | 0.376 | 1.025 (0.706–1.488) | 0.896 | rs9847368 | 0.864 (0.535–1.394) | 0.549 | 1.066 (0.230–4.926) | 0.935 | 0.891 (0.578–1.375) | 0.604 | rs114342639 | 0.929 (0.615–1.399) | 0.721 | 0.811 (0.277–2.368) | 0.701 | 0.924 (0.650–1.315) | 0.663 | rs3773644 | 0.799 (0.534–1.195) | 0.275 | 1.008 (0.583–1.742) | 0.977 | 0.894 (0.669–1.196) | 0.452 | rs3773652 | 1.199 (0.753–1.909) | 0.444 | 1.277 (0.816–1.997) | 0.283 | 1.176 (0.887–1.558) | 0.260 | rs2043136 | 0.954 (0.624–1.459) | 0.827 | 0.864 (0.496–1.508) | 0.608 | 0.936 (0.696–1.26) | 0.665 | rs876688 | 1.188 (0.800–1.763) | 0.392 | 1.98 (0.965–4.059) | 0.062 | 1.259 (0.917–1.727) | 0.153 |
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: value was calculated using logistic regression analysis. |