Antimalarial Activity and Toxicological Assessment of Betula alnoides Extract against Plasmodium berghei Infections in Mice

Table 1

Four-day suppressive activity of the aqueous stem extract of B. alnoides compared with the suppressive activities of artesunate and the negative control against P. berghei-infected mice.

Groups	% parasitaemia	% suppression	MST (days)
Negative control	15.96 ± 0.06	—	5.5 ± 0.50
Artesunate 6 mg/kg	0.62 ± 0.38^a,b,c	96.13 ± 2.38	9.0 ± 1.00
Extract 200 mg/kg	8.50 ± 0.17^a	46.90 ± 1.07	8.5 ± 0.50
Extract 400 mg/kg	6.66 ± 0.18^a,b	58.39 ± 1.15	15.0 ± 1.30^d
Extract 600 mg/kg	4.60 ± 0.22^a,b,c	71.26 ± 1.40	22.5 ± 1.19^d,e

Data are expressed as the mean ± SEM (n = 6/group), MST: mean survival time. Values are significantly different at . ^aSignificantly lower than that of the negative control. ^bSignificantly lower than those of the groups treated with 200 mg/kg extract. ^cSignificantly lower than those of the groups treated with 400 mg/kg extract. ^dSignificantly longer than those of the negative control and the groups treated with artesunate and 200 mg/kg extract. ^eSignificantly longer than those of the negative control and the groups treated with 400 mg/kg extract.