Antimalarial Activity and Toxicological Assessment of Betula alnoides Extract against Plasmodium berghei Infections in Mice

Table 2

Effect of aqueous stem extract of B. alnoides on the body weights of infected mice in a 4-day suppressive test.

Groups	Mean body weight (g)		% change
	Day 0	Day 4
Negative control	29.80 ± 2.12	24.95 ± 1.67	−16.25 ± 0.49
Artesunate 6 mg/kg	31.60 ± 1.35	30.45 ± 0.89	−3.57 ± 1.82^b
Extract 200 mg/kg	28.89 ± 1.83	25.55 ± 1.48^a	−11.47 ± 0.91^b,c
Extract 400 mg/kg	28.99 ± 0.81	26.49 ± 0.77^a	−8.65 ± 0.68^b,c
Extract 600 mg/kg	28.37 ± 0.99	26.16 ± 0.97^a	−7.80 ± 0.30^b,d

Data are expressed as the mean ± SEM (n = 6/group), day 0: before treatment; day 4: after completing treatment. ^aSignificantly higher than that of the negative control. ^bSignificantly higher than that of the negative control. ^cSignificantly higher than those of the groups treated with artesunate. ^dSignificantly higher than those of the groups treated with 200 mg/kg extract.