Antimalarial Activity and Toxicological Assessment of Betula alnoides Extract against Plasmodium berghei Infections in Mice

Table 3

Evaluation of food and water consumption by both the negative control group and the group treated with the aqueous stem extract of B. alnoides at the dose of 5000 mg/kg.

Parameters	Negative control	5000 mg/kg extract
Food consumption (g)
Week 1: days 1–3	20.30 ± 0.67	37.67 ± 1.17^a,1
Week 1: days 4–7	19.00 ± 0.41	20.25 ± 0.63
Week 2: days 8–14	19.29 ± 0.41	19.71 ± 0.46
Water consumption (mL)
Week 1: days 1–3	19.67 ± 0.33	37.00 ± 2.00^b,2
Week 1: days 4–7	20.25 ± 0.63	21.75 ± 0.63
Week 3: days 8–14	18.43 ± 0.43	28.86 ± 0.47

Data are expressed as the mean ± SEM (n = 6/group). ^aSignificantly higher food consumption than that of negative control. ¹Significantly higher food consumption than those of the groups treated with 5000 mg/kg extract on days 4–7 and days 8–14. ^bSignificantly higher water consumption than that of the negative control. ²Significantly higher water consumption than those of the groups treated with 5000 mg/kg extract on days 4–7 and days 8–14.