Research Article
Novel Acaricidal Drug Fluazuron Causes Immunotoxicity via Selective Depletion of Lymphocytes T CD8
Table 1
Computational analysis of probable toxicity mechanisms for Fluazuron using the PROTOX-II Platform [
8].
| Target | Prediction | Probability |
| Hepatotoxicity | Active | 0.72 | Carcinogenicity | Active | 0.56 | Immunotoxicity | Active | 0.55 | Mutagenicity | Inactive | 0.93 | Cytotoxicity | Active | 0.51 | Aryl hydrocarbon Receptor (AhR) | Inactive | 0.90 | Androgen Receptor (AR) | Inactive | 1.0 | Androgen Receptor Ligand Binding Domain (AR-LBD) | Inactive | 0.99 | Aromatase | Inactive | 0.97 | Estrogen Receptor Alpha (ER) | Inactive | 0.98 | Estrogen Receptor Ligand Binding Domain (ER-LBD) | Inactive | 1.0 | Peroxisome Proliferator Activated Receptor Gamma | Inactive | 0.78 | Heat shock factor response element (HSE) | Inactive | 0.97 | Mitochondrial Membrane Potential (MMP) | Active | 1.0 | Phosphoprotein (Tumor Suppressor) p53 | Active | 1.0 | ATPase family AAA domain-containing protein 5 | Inactive | 0.99 |
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