Novel Acaricidal Drug Fluazuron Causes Immunotoxicity via Selective Depletion of Lymphocytes T CD8

Table 1

Computational analysis of probable toxicity mechanisms for Fluazuron using the PROTOX-II Platform [8].

Target	Prediction	Probability
Hepatotoxicity	Active	0.72
Carcinogenicity	Active	0.56
Immunotoxicity	Active	0.55
Mutagenicity	Inactive	0.93
Cytotoxicity	Active	0.51
Aryl hydrocarbon Receptor (AhR)	Inactive	0.90
Androgen Receptor (AR)	Inactive	1.0
Androgen Receptor Ligand Binding Domain (AR-LBD)	Inactive	0.99
Aromatase	Inactive	0.97
Estrogen Receptor Alpha (ER)	Inactive	0.98
Estrogen Receptor Ligand Binding Domain (ER-LBD)	Inactive	1.0
Peroxisome Proliferator Activated Receptor Gamma	Inactive	0.78
Heat shock factor response element (HSE)	Inactive	0.97
Mitochondrial Membrane Potential (MMP)	Active	1.0
Phosphoprotein (Tumor Suppressor) p53	Active	1.0
ATPase family AAA domain-containing protein 5	Inactive	0.99