Establishment of Mouse Models of Psoriasis with Blood Stasis Syndrome Complicated with Glucose and Lipid Metabolism Disorders

Figure 1

Induction methods and establishment of mouse psoriasis models. (a) Induction methods involving IMQ, STZ, and BSS. (b) After induction, skin lesions on the back of mice in each group were recorded for seven days. (c) After induction, the PASI score of back-skin lesions in each group was determined for seven days. (d) After induction, ear thickness in each group was measured for seven days. (e) Left: pathological sections of mouse back skin (H&E staining; magnification, ×100; scale bar, 100 μM) showed thickening of the epidermis in each group on the last day of induction. Right: immunohistochemical analysis of mouse back skin (magnification, ×200; scale bar, 50 μM); brown-yellow granule cells indicate STAT3-positive cells. (f) Comparison of epidermis thickness on the last day of induction. (g) Infiltration degree of STAT3 on the last day of induction. Compared with the control group, , ; compared with the IMQ group, , .

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