Study on the Multitarget Mechanism and Key Active Ingredients of Herba Siegesbeckiae and Volatile Oil against Rheumatoid Arthritis Based on Network Pharmacology

Table 2

Chemical composition and target molecule docking.

Tagret	Degree	Volatile oil (GS-MS)	Degree	Compounds (TCMSP)	Degree
CSF2	16	Phytol	7	Vernolic acid	7
IL1β	16	Heptacosane	7	L-α-Palmitin	7
TNF	14	Hexahydrofarnesyl acetone	6	Methyl icosanoate	5
IL6	11	Nonanoic acid	4	3-(α,4-Dihydroxy-3-methoxybenzyl)-4-(hydroxy-3-methoxybenzyl) tetrahydrofuran	4
IL18	9	Nonanal	4	Orientin	3
CD28	6	Pentacosane	3	Henicosanol	3
IFNG	6	ar-curcumene	2	Orixine	3
CTLA4	4	Oplopenone	1	Carboceric acid	3
		Nerol	1	Chromolaevanedione	2
				Ferulic acid	2
				Stigmasterol	2
				Darutoside	2
				β-Sitosterol	1
				Hederagenin	1
				Stigmasterol-β-D-glucoside	1
				Alexandrin	1