Sesamin, a Naturally Occurring Lignan, Inhibits Ligand-Induced Lipogenesis through Interaction with Liver X Receptor Alpha (LXR<i>α</i>) and Pregnane X Receptor (PXR)

<div>Schematic model of the LXR pathways in liver and intestinal cells and the action of sesamin on LXR<i>α</i> and PXR. Sesamin selectively reduced hepatic lipogenesis via the inhibition of SREBP-1c expression and its downstream target genes; however, genes involved in RCT of intestinal cells were preserved. It inhibited the hepatic lipogenesis partially via AMPK activation and increased SMILE recruitment to the SREBP-1c promoter. These effects were opposite in intestinal cells, where it did not recruit SMILE but competitively increased SRC-1 binding to the ABCG1 promoter region.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 7

Figure 7: Sesamin, a Naturally Occurring Lignan, Inhibits Ligand-Induced Lipogenesis through Interaction with Liver X Receptor Alpha (LXR<i>α</i>) and Pregnane X Receptor (PXR) 

Figure 7 | Sesamin, a Naturally Occurring Lignan, Inhibits Ligand-Induced Lipogenesis through Interaction with Liver X Receptor Alpha (LXRα) and Pregnane X Receptor (PXR) 