Review Article

Medicinal Properties and Active Constituents of Dracocephalum kotschyi and Its Significance in Iran: A Systematic Review

Table 1

Main components in D. kotschyi from different studies and provinces.

No.ProvinceExtract (area) Method of identificationMajor constituents References

1Aladagh mountains
(3000 m) near Bojnord in North Khorasan
Essential oil (Flower) GC‐MS.Citral, Caryophyllene, terpinyl acetate, myrcene, and Menthone[51]

2Bojnord, North Khorasan,Essential oil (Flower) GC-MSLimonene, verbenone, α-terpineol, perillyl alcohol and Caryophyllene[23]

3Suburb of Sari, Mazandaran province, North of IranEssential oil (Aerial part) GC-MSδ -3-carene, limonene, carvacrol, 1,8-cineole and carvone.[52]

4Muteh protected region, Isfahan provinceEssential oil (Aerial part) GC-MSα-pinene, caryophyllene oxide, terpinen- 4-ol and germacrene D.[50]

5Tochal Mountain near to TehranEssential oil (Whole plant) GC-MSGeranial, limonene-10-al, limonene and 1,1-dimethoxydecane[45]

6Garin mountains (3200 m) near to Alshtar in the of province LorestanEssential oil (Aerial part) GC-MSGeranial, α-Pinene, Geraniol acetate, Geraniol, Neral and Limonene.[8]

7Fars provincePowder (flower) GC-MSLinolenic acid, oleic and Linoleic acids[53]

8IsfahanEssential oil (Flower and roots) GC-MSGeraniol, geranyl acetate (trace) and neryl acetate.[54]

9LorestanPowder (Leaf) GC-MSFlavonoids, Tannins[51]

10North Khorasan ProvinceAerial parts (Powder) GC-MSLuteolin[55]

11Isfahan and TehranPowder (Leaf) GC-MSXanthomicrol[56]

12IsfahanAerial part (green extract) ObservationGreen extract[49]

13MazandaranEssential oil (Aerial parts) GC-MS Limonene, α-terpineol and α-pinene[57]

14AlborzWhole plant GC-MSFlavonoids, calycopterin, anthomicrol, isokaempferide, luteol, apigenin, g), luteolin 7-O-β-D-glucopyranoside, phenolic, rosmarinic acid[10]

15Sari in MazandaranEssential oil (Aerial parts) GC-MSLimonene, carvacrol, γ-terpinene, α -pinene, 2-methyl-1-octen-3-yne, camphene, myrcene and α –terpinene.[48]

16MazandaranEssence of the shoots GC-MSLimonene, cyclohexene, α-pinene, Sylosyfon, trans-limonene oxide.[59]

17Kansar–IsfahanEssential oil (Aerial part –Flower) GC-MS Limonene-10-al, limonene[60]

18Muteh protected region in IsfahanEssential oil
(Aerial parts of the plant)
GC-MSα -pinene, caryophyllene oxide, terpinen- 4-ol and germacrene D.[54]

19IsfahanEssential oils GC-MSLongibornyl and acetate.[49]

20Khorasan(Aerial parts and roots) HPLC and GC- MSLuteolin, quercetin and apigenin, phenolic, Gallic acid[62]

21KhorasanEssential oil (Aerial parts) HPLC, MS and NMRGeranial, limonene and 1, 1-dimethoxydecane.[62]

22IsfahanAerial parts GC-MSFlavonoid aglycones (luteolin, naringenin, apigenin, isokaempferide, cirsimaritin, penduletin, xanthomicrol and calycopterin).[25]

23Mountain, Alborz, north of TehranDried whole plants GC–MSTerpenoids and a phytosterol (1—8) [limonen-10-al, geranial, neral, b -sitosterol, oleanolic acid, ursolic acid, p-mentha-8-en-1,2-diol, colosolic acid, limonen-10-ol 10-O-b -D-glucopyranoside, and limonen-10-ol 10-O-b -D-glucopyranosyl-(1Æ2)-b –D glucopyranoside).[11]

24TehranAerial parts of the plant GC-MSa-pinene, methyl geranate, b-ocimene, and limonene, a-Pinene, methyl geranate, limonene, b-ocimene, geraniol trans-verbenol, and terpinen-4-ol.[44, 63]

25TehranWhole plant GC-MSFlavonoids luteolin-7-O-glucoside, apigenin-7-O-glucoside (cosmosiin), luteolin 3′-O-β-d-glucuronide, luteolin, apigenin, cirsimaritin, isokaempferide, penduletin, xanthomicrol, calycopterin and the polyphenol rosmarinic acid[64]

26IsfahanAerial parts GC-MSCitral, p-mentha-1,3,8-triene, D-3-carene and methyl geranate[65]

27IsfahanWhole plant GC-MSApigenin[45]

28 TehranEssential oil Aerial part of the plant MTT EssayLimonene, Geranial, 1,1-Dimethoxy decane, C10 H14O, CxHy, CxHyOz, Unidentified compound[39]

29TehranLeaf GC-MSLimonene, limonene-10-al, 1,1-dimethoxy decane, cyclic monoterpenes[18]

30Bojnord and the surrounding areas in North KhorasanEssential oil Aerial parts GC-MSTrans-citral (geranial), eucalyptol, limonene, beta-linalool, neryl-acetate and myrcene.[17]

31IsfahanPowder (Aerial part) GC-MSLuteolin, Naringenin, Apigenin, kaempferoide, Cirsimaritin, Penduletin Xanthomicrol, Calycoperin[49]

32Northeastern IranLeaf MTT EssayCitral, caryophyllene, terpinyl acetate, and myrcene[24]

33TehranPowder (Seeds and leaf) GC-MSXanthomicrol ((5,4′-dihydroxy-6,7,8-trimethoxyflavone)[66]

34IsfahanPowder (Aerial part)GC-MSCalycopterin[31]

35West AzerbaijanWhole plant (extract)GC-MS(E)-β-ocimene, nerol, nerol/methyl, geranate, and α-pinene/geranial/ geraniol[14]

36IsfahamEssential oil (Aerial parts)GC-MS(flavonoids) luteolin-7-O-glucoside, apigenin-7-O-glucoside (cosmosiin), luteolin 3′-O-β-d-glucuronide, luteolin, apigenin, cirsimaritin, isokaempferide, penduletin, xanthomicrol, calycopterin and the polyphenol rosmarinic acid[66]

37TehranGC-MSArosmarinic acid, flavonoids
Limonene, neral, geranial,
geraniol, geranyl acetate, α-terpineol, trans-verbenol, carvon, and transcarveol
[62, 63]

38AzerbaijanWhole plant (Powder) GC-MSLimonene, neral, geranial, β-sitosteral, Oleanolic acid, Ursolic acic, p-metha-8-en-1,2-diol, colosonic acid, limonen-10-ol-O-βglucopyranoside, limonen-10-ol-O-βglucopyranosyl-(1→2)- βglucopyranoside[11]

Note: GC-MS: gas chromatography-mass spectrometry; MTT: Ministerio de Transportes y Telecomunicacione; HPLC: high-performance liquid chromatography; NMR: nuclear magnetic resonance.