Research Article
Integrated Chinese Herbal Medicine and Western Medicine on the Survival in Patients with Colorectal Cancer: A Retrospective Study of Medical Records
Table 3
Survival of patients with colorectal cancer (N = 535).
| Variable | Unadjusted analysis | Adjusted analysis | HR | 95% CI | | Adjusted HR | 95% CI | |
| Chinese herbal medicine use | Nonusers (<30d) | 1.00 | | | 1.00 | | | Users (≥30 d) | 0.62 | 0.44–0.88 | 0.007 | 0.54 | 0.38–0.77 | 0.001 | Age (years) | ≤45 | 1.00 | | | — | — | — | 46–65 | 0.52 | 0.31–0.88 | 0.014 | — | — | — | >65 | 0.95 | 0.59–1.52 | 0.820 | — | — | — | Sex | Female | 1.00 | | | — | — | — | Male | 1.29 | 0.97–1.72 | 0.076 | — | — | — | Clinical stage | I | 1.00 | | | 1.00 | | | II | 3.25 | 1.58–6.70 | 0.001 | 2.98 | 1.44–6.18 | 0.003 | III | 3.30 | 1.69–6.42 | <0.001 | 4.28 | 2.18–8.42 | <0.001 | IV | 15.26 | 7.93–29.36 | <0.001 | 17.49 | 8.90–34.38 | <0.001 | Surgery | 0.18 | 0.12–0.26 | <0.001 | 0.29 | 0.19–0.43 | <0.001 | Radiotherapy | 0.82 | 0.60–1.12 | 0.215 | — | — | — | Chemotherapy | 0.76 | 0.56–1.02 | 0.069 | 0.47 | 0.34–0.65 | <0.001 | Distant metastases | 5.69 | 4.27–7.57 | <0.001 | — | — | — | Comorbidity score 1 | 1.04 | 0.61–1.75 | 0.896 | — | — | — | Comorbidity score 2 | 0.59 | 0.28–1.24 | 0.165 | — | — | — | Comorbidity score 6 | 1.48 | 0.86–2.55 | 0.161 | — | — | — |
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CI: confidence interval; HR: hazards ratio. Comorbidity score 1: myocardial infarction, congestive heart failure, peripheral vascular disease, cerebrovascular disease, dementia, chronic pulmonary disease, rheumatologic disease, peptic ulcer disease, mild liver disease, and diabetes. Comorbidity score 2: diabetes with chronic complication, hemiplegia or paraplegia, renal disease, and malignancy (including leukemia and lymphoma). Comorbidity score 6: metastases solid tumor and acquired immune deficiency syndrome.
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