A Systems Pharmacology Approach for Identifying the Multiple Mechanisms of Action for the Rougui-Fuzi Herb Pair in the Treatment of Cardiocerebral Vascular Diseases

Table 4

UPLC-Q-Exactive-MS^E results of the bioactive ingredients in the extract of rougui-fuzi.

Number	Compound		Area	RT (meas)	Formula	Measured m/z	Fragment ion	Delta m/z	Adducts
1	Senbusine C	+	1.2E + 08	6.49	C24H39NO7	454.28	436.2688, 404.2440, 409.6704	−0.05	H+
2	Aconine	+	7550000	5.73	C25H41NO9	500.285	154.9902, 182.9852, 226.9514	0.53	H+
3	Cinnamic acid	+	2260000	10.46	C9H8O2	149.06	167.1029, 362.9263, 243.9417	0.6	H+
4	Coumarin	+	8.2E + 07	10.55	C9H6O2	147.044	154.9902, 167.0128, 226.9513	0.36	H+
5	Mesaconitine	+	79300	12.07	C33H45NO11	632.307	124.0870, 154.9902, 167.0128	2.86	H+
6	Benzoylhypaconine	+	3.3E + 07	12.23	C31H43NO9	574.301	226.9514, 154.9903, 362.9263	0.15	H+
7	Hypaconitine	+	636000	12.49	C33H45NO10	616.312	226.9513, 124.0869, 167.0128	−0.26	H+
8	Cinnamaldehyde	+	2E + 08	13.36	C9H8O	133.065	133.0648, 154.9903, 167.0129	0.45	H+