Natural bioactives or phytochemicals is generally referred to the compounds exclusive of essential nutrients that have specific biological activity to human. It has been known that over 10,000 different phytochemicals possess the potential preventive or supplementary effect on various diseases. From several decades ago to now, cancer continues to be the leading-lethal cause worldwide. Studies have shown that natural phytochemicals derived from certain plants have the capability to prevent carcinogenesis. Therefore, new active compounds responsible for the cancer-against characteristics of dietary plants and original active compounds exert novel function on anti-carcinogenesis are important issues for cancer investigation.

Although some cancer can be cured initially, following the diagnosis of cancer, chemotherapy is used to prevent a local recurrence and spread of the primary tumor. However, the effective dose of chemotherapeutics may result in severe side effects. To reduce the suffering and enhance the survival of cancer patients, the treatment and prevention of cancer assist with natural bioactives or phytochemicals is regarded as a valid strategy in cancer therapy.

We invite the researchers to contribute original and review articles regarding the relation between phytochemicals and cancers, including the discovery of novel anti-cancer phytochemicals and the clinical application of phytochemicals on cancer treatment. Potential topics include, but are not limited to:

• Bioactivity or toxicology of phytochemicals
• Pharmacology or pharmaceutics of phytochemicals
• Discovery of new natural bioactives or phytochemicals
• New cancer therapy by phytochemicals
• SAR studies (structure/activity relationship) of cancer preventive natural compounds
• Natural metabolites as lead compounds for cancer prevention
• Cancer preventive natural substances: from bench to bedside
• The possible adverse effects or interaction between phytochemicals, such as conventional herb-neutraceutical interaction

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