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Phytomedicines against Liver Diseases: Prospects and Challenges

Call for Papers

Liver disease is a serious health problem, affecting over 10% of the world population. Common liver diseases include acute and chronic hepatitis, alcoholic steatosis, fibrosis, cirrhosis and hepatocellular carcinoma. Although therapeutic management exist for some liver ailments, the majority remains incurable. Additionally, for viral hepatitis and hepatocellular carcinoma, the emergence of drug resistance is adding further complexities to the existing scenario. Therefore, there is a pressing need for developing novel treatment approaches against liver diseases. Nearly half of the agents used worldwide in liver therapy today seem to be either natural products or derivatives of natural products. Indeed various herbal preparations and liver care type supplements are available. Few natural products (and derived phytoconstituents) including Silybum marianum and Emblica officinalis appear to have gained global attention in finding new hepatoprotective remedies of plant origin. By now, a plethora of literature is available on such studies and it is timely to review the field critically.

We invite researchers working on relevant theme to contribute original research articles as well as review articles that will update us with the existing herbal resources with proven efficacy in providing liver protection and ameliorating/reverting various liver diseases. Research articles published in this special issue should include controlled experiments and any clinical studies include randomization of patients and the data is analyzed blindly. We are particularly interested to know about the natural products and studies where, instead of merely reporting hepatoprotective values of crude plant extracts, researchers have at least identified and characterised the most bioactive fraction(s) as well as the active ingredient(s) and addressed the possible mechanism of action of the active product. Potential topics include, but are not limited to:

  • Evaluation of various common in vivo and ex vivo models of liver diseases that are commonly used by the natural product scientist as bioassays for hepatoprotectivity
  • Global ethnopharmacological practices against liver diseases
  • Medicinal plants and phytochemicals against liver diseases
  • Herb-drug interactions in the management of liver diseases
  • Quality assurance of phytomedicines for treating liver diseases

Before submission, authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ecam/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/ecam/phytol/ according to the following timetable:

Manuscript DueFriday, 25 July 2014
First Round of ReviewsFriday, 17 October 2014
Publication DateFriday, 12 December 2014

Lead Guest Editor

  • Mohammed Rahmatullah, Pro-Vice Chancellor and Dean, Faculty of Life Sciences, University of Development Alternative, Dhaka, Bangladesh

Guest Editors

  • Pierre Duez, Department of Therapeutical Chemistry and Pharmacognosy, University of Mons (UMONS), 7000 Mons, Belgium
  • Chang-Gue Son, Liver and Immunology Research Center, Institute of Traditional Medicine and Bioscience of Daejeon University, Daejeon, Republic of Korea
  • Taufiq Rahman, Department of Pharmacology, University of Cambridge, Cambridge CB2 1TN, UK