| Figure 7: Expression of the receptors of neurotrophic
factors in dorsal root ganglia in 8-month type 1 diabetic (D1) and type 2
diabetic (D2) rats, as well as type 1 rats replaced with C-peptide. (c) compared to age-matched control rats
. Note marked decreases in the expression of insulin receptor, IGF-1 receptor, and NGF-TrkA receptor in type 1
rats. These defects were significantly
milder in type 2 diabetic rats and were significantly prevented by C-peptide
replacement in type 1 diabetic rats [50]. |
|
