]>Rosiglitazone Prevents High Glucose-Induced Vascular Endothelial Growth Factor and Collagen IV Expression in Cultured Mesangial Cells : Figure 3
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Figure 3: NADPH oxidase subunit p2 2 p h o x expression. Mesangial cells were exposed to 5.6 mM (NG) or 25 mM (HG) D-glucose for 24 hours or 48 hours, or pretreated with 10  𝜇 M rosiglitazone (RSG), or 10  𝜇 M ciglitazone or 10  𝜇 M troglitazone) and p2 2 p h o x was detected by immunoblotting. Pretreatment with three different PPAR 𝛾 agonists blocked HG-induced p2 2 p h o x expression ( 𝑛 = 5 , ∗ 𝑃 < . 0 5 versus NG, ∗ ∗ 𝑃 < . 0 5 versus HG 24 hours or HG 48 hours).