Pharmacological Modulation of Dopamine Receptor D2-Mediated Transmission Alters the Metabolic Phenotype of Diet Induced Obese and Diet Resistant C57Bl6 Mice

Table 1

Plasma glucose, insulin, free glycerol, and NEFA concentrations during the basal and hyperinsulinemic conditions of the hyperinsulinemic euglycemic clamp in DIO and DR mice after treatment with bromocriptine, haloperidol, or placebo for 2 weeks.

	Clamp condition	DIO mice		DR mice
		Placebo	Bromocriptine	Placebo	Haloperidol
Glucose (mM)	Basal	5.9±0.6	5.3±1.1	5.0±0.6	6.7±1.7
	Hyperinsulinemia	5.4±0.7	5.6±0.6	6.0±0.7	4.8±1.1
Insulin (μg/L)	Basal	2.4±0.3	2.0±0.8	1.6±0.5	2.6±0.7
	Hyperinsulinemia	6.8±1.9	7.2±1.4	6.7±1.3	7.1±0.6
Free glycerol (mM)	Basal	0.1±0.1	0.1±0.1	0.2±0.1	0.2±0.1
	Hyperinsulinemia	0.1±0.0	0.1±0.0	0.1±0.0	0.1±0.0
NEFA (mM)	Basal	1.0±0.2	1.1±0.3	1.1±0.2	1.0±0.3
	Hyperinsulinemia	0.5±0.1	0.5±0.1	0.5±0.2	0.5±0.1

Data is measured in 9 or 10 mice and presented as mean ± SD.