New Experimental Models of Diabetic Nephropathy in Mice Models of Type 2 Diabetes: Efforts to Replicate Human Nephropathy

Figure 1

Established DN in humans: (a) glomerular basement membrane thickening by electron microscope. (b) Glomerular nodules in DN with intensively positive staining by methenamine silver. Nodular glomerulosclerosis: (c) hematoxilin eosine staining, (d) periodic acid-schiff stain demonstrates the mesangial nodules and esclerosis glomerular. (e) nodular diabetic glomerulosclerosis by Masson’s trichrome staining, (Magnification ×400) in collaboration with Dr. Javier Gimeno.