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Emergency Medicine International
Volume 2012 (2012), Article ID 815857, 9 pages
http://dx.doi.org/10.1155/2012/815857
Review Article

Current Pharmacological Advances in the Treatment of Cardiac Arrest

Intensive Care Unit, Evagelismos Hospital, 45-47 Ipsilantou Street, Athens 10676, Greece

Received 11 August 2011; Accepted 6 September 2011

Academic Editor: Michael Winters

Copyright © 2012 Andry Papastylianou and S. Mentzelopoulos. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. P. Zipes and H. J. Wellens, “Sudden cardiac death,” Circulation, vol. 98, no. 21, pp. 2334–2351, 1998. View at Scopus
  2. C. Atwood, M. S. Eisenberg, J. Herlitz, and T. D. Rea, “Incidence of EMS-treated out-of-hospital cardiac arrest in Europe,” Resuscitation, vol. 67, no. 1, pp. 75–80, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. G. Nichol, E. Thomas, C. W. Callaway et al., “Regional variation in out-of-hospital cardiac arrest incidence and outcome,” Journal of the American Medical Association, vol. 300, no. 12, pp. 1423–1431, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. C. Sandroni, J. Nolan, F. Cavallaro, and M. Antonelli, “In-hospital cardiac arrest: incidence, prognosis and possible measures to improve survival,” Intensive Care Medicine, vol. 33, no. 2, pp. 237–245, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. P. A. Meaney, V. M. Nadkarni, K. B. Kern, J. H. Indik, H. R. Halperin, and R. A. Berg, “Rhythms and outcomes of adult in-hospital cardiac arrest,” Critical Care Medicine, vol. 38, no. 1, pp. 101–108, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. R. W. Neumar, C. W. Otto, M. S. Link et al., “2010 American heart association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care science part 8: adult advanced cardiovascular life support,” Circulation, vol. 122, no. 3, pp. S729–S767, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. R. Gottlieb, “Ueber die wirkung der nebennieren extracte auf herz und blutdruck,” Archiv für Experimentelle Pathologie und Pharmakologie, vol. 38, no. 1-2, pp. 99–112, 1897. View at Publisher · View at Google Scholar
  8. M. Callaham, C. D. Madsen, C. W. Barton, C. E. Saunders, and J. Pointer, “A randomized clinical trial of high-dose epinephrine and norepinephrine vs standard-dose epinephrine in prehospital cardiac arrest,” Journal of the American Medical Association, vol. 268, no. 19, pp. 2667–2672, 1992. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Silfvast, L. Saarnivaara, and A. Kinnunen, “Comparison of adrenaline and phenylephrine in out-of-hospital cardiopulmonary resuscitation. A double-blind study,” Acta Anaesthesiologica Scandinavica, vol. 29, no. 6, pp. 610–613, 1985.
  10. M. Fries, W. Tang, Y. T. Chang, J. Wang, C. Castillo, and M. H. Weil, “Microvascular blood flow during cardiopulmonary resuscitation is predictive of outcome,” Resuscitation, vol. 71, no. 2, pp. 248–253, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. M. G. Angelos, R. L. Butke, A. R. Panchal et al., “Cardiovascular response to epinephrine varies with increasing duration of cardiac arrest,” Resuscitation, vol. 77, no. 1, pp. 101–110, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. T. M. Olasveengen, K. Sunde, C. Brunborg, J. Thowsen, P. A. Steen, and L. Wik, “Intravenous drug administration during out-of-hospital cardiac arrest: a randomized trial,” Journal of the American Medical Association, vol. 302, no. 20, pp. 2222–2229, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. J. Herlitz, L. Ekstrom, B. Wennerblom, A. Axelsson, A. Bang, and S. Holmberg, “Adrenaline in out-of-hospital ventricular fibrillation. Does it make any difference?” Resuscitation, vol. 29, no. 3, pp. 195–201, 1995. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Vandycke and P. Martens, “High dose versus standard dose epinephrine in cardiac arrest—a meta- analysis,” Resuscitation, vol. 45, no. 3, pp. 161–166, 2000. View at Publisher · View at Google Scholar · View at Scopus
  15. C. F. Babbs, R. A. Berg, F. Kette et al., “Use of pressors in the treatment of cardiac arrest,” Annals of Emergency Medicine, vol. 37, no. 4, pp. S152–S162, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. U. Hornchen, C. Lussi, and J. Schuttler, “Potential risks of high-dose epinephrine for resuscitation from ventricular fibrillation in a porcine model,” Journal of Cardiothoracic and Vascular Anesthesia, vol. 7, no. 2, pp. 184–187, 1993. View at Publisher · View at Google Scholar · View at Scopus
  17. R. Neumar, N. Bircher, M. Radovsky, et al., “Myocardial necrosis after high dose epinephrine during CPR,” Annals of Emergency Medicine, vol. 22, pp. 892–893, 1993.
  18. W. Tang, M. H. Weil, S. Sun, M. Noc, L. Yang, and R. J. Gazmuri, “Epinephrine increases the severity of postresuscitation myocardial dysfunction,” Circulation, vol. 92, no. 10, pp. 3089–3093, 1995. View at Scopus
  19. R. A. Berg, C. W. Otto, K. B. Kern et al., “High-dose epinephrine results in greater early mortality after resuscitation from prolonged cardiac arrest in pigs: a prospective, randomized study,” Critical Care Medicine, vol. 22, no. 2, pp. 282–290, 1994. View at Scopus
  20. J. P. Nolan, J. Soar, D. A. Zideman et al., “European resuscitation council guidelines for resuscitation 2010 section 1. Executive summary,” Resuscitation, vol. 81, no. 10, pp. 1219–1276, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. K. H. Lindner, T. Haak, A. Keller, U. Bothner, and K. G. Lurie, “Release of endogenous vasopressors during and after cardiopulmonary resuscitation,” Heart, vol. 75, no. 2, pp. 145–150, 1996. View at Scopus
  22. D. K. Sreevastava, P. K. Roy, S. K. Dass et al., “Cardio-pulmonary resuscitation: an overview of recent advances in concepts and practices,” Medical Journal Armed Forces India, vol. 60, no. 1, pp. 52–58, 2004. View at Scopus
  23. K. H. Lindner, A. W. Prengel, E. G. Pfenninger et al., “Vasopressin improves vital organ blood flow during closed-chest cardiopulmonary resuscitation in pigs,” Circulation, vol. 91, no. 1, pp. 215–221, 1995. View at Scopus
  24. A. W. Prengel, K. H. Lindner, and A. Keller, “Cerebral oxygenation during cardiopulmonary resuscitation with epinephrine and vasopressin in pigs,” Stroke, vol. 27, no. 7, pp. 1241–1248, 1996. View at Scopus
  25. V. Wenzel, K. H. Lindner, A. C. Krismer, E. A. Miller, W. G. Voelckel, and W. Lingnau, “Repeated administration of vasopressin but not epinephrine maintains coronary perfusion pressure after early and late administration during prolonged cardiopulmonary resuscitation in pigs,” Circulation, vol. 99, no. 10, pp. 1379–1384, 1999. View at Scopus
  26. V. Wenzel, K. H. Lindner, A. C. Krismer et al., “Survival with full neurologic recovery and no cerebral pathology after prolonged cardiopulmonary resuscitation with vasopressin in pigs,” Journal of the American College of Cardiology, vol. 35, no. 2, pp. 527–533, 2000. View at Publisher · View at Google Scholar · View at Scopus
  27. V. D. Mayr, V. Wenzel, W. G. Voelckel et al., “Developing a vasopressor combination in a pig model of adult asphyxial cardiac arrest,” Circulation, vol. 104, no. 14, pp. 1651–1656, 2001. View at Scopus
  28. K. H. Lindner, B. Dirks, H. U. Strohmenger, A. W. Prengel, I. M. Lindner, and K. G. Lurie, “Randomised comparison of epinephrine and vasopressin in patients with out-of-hospital ventricular fibrillation,” The Lancet, vol. 349, no. 9051, pp. 535–537, 1997. View at Publisher · View at Google Scholar · View at Scopus
  29. I. G. Stiell, P. C. Hebert, G. A. Wells et al., “Vasopressin versus epinephrine for inhospital cardiac arrest: a randomised controlled trial,” The Lancet, vol. 358, no. 9276, pp. 105–109, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. V. Wenzel, A. C. Krismer, H. R. Arntz, H. Sitter, K. H. Stadlbauer, and K. H. Lindner, “A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation,” The New England Journal of Medicine, vol. 350, no. 2, pp. 105–113, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. K. Aung and T. Htay, “Vasopressin for cardiac arrest: a systematic review and meta-analysis,” Archives of Internal Medicine, vol. 165, no. 1, pp. 17–24, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  32. C. W. Callaway, D. Hostler, A. A. Doshi et al., “Usefulness of vasopressin administered with epinephrine during out-of-hospital cardiac arrest,” American Journal of Cardiology, vol. 98, no. 10, pp. 1316–1321, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  33. P. Y. Gueugniaud, J. S. David, E. Chanzy et al., “Vasopressin and epinephrine vs. epinephrine alone in cardiopulmonary resuscitation,” The New England Journal of Medicine, vol. 359, no. 1, pp. 21–30, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. S. Mally, A. Jelatancev, and S. Grmec, “Effects of epinephrine and vasopressin on end-tidal carbon dioxide tension and mean arterial blood pressure in out-of-hospital cardiopulmonary resuscitation: an observational study,” Critical Care, vol. 11, no. 2, Article ID R39, 2007. View at Publisher · View at Google Scholar · View at PubMed
  35. S. D. Mentzelopoulos, S. G. Zakynthinos, M. Tzoufi et al., “Vasopressin, epinephrine, and corticosteroids for in-hospital cardiac arrest,” Archives of Internal Medicine, vol. 169, no. 1, pp. 15–24, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  36. “Guidelines 2000 for cardiopulmonary resuscitation and emergency cardiovascular care: an international consensus on science. 6. Advanced cardiovascular life support. 5. Pharmacology I: agents for arrhythmias,” Circulation, vol. 102, supplement 1, pp. 112–128, 2000.
  37. E. Masini, J. Planchenault, F. Pezziardi, P. Gautier, and J. P. Gagnol, “Histamine-releasing properties of Polysorbate 80 in vitro and in vivo: correlation with its hypotensive action in the dog,” Agents and Actions, vol. 16, no. 6, pp. 470–477, 1985. View at Scopus
  38. J. C. Somberg, S. Timar, S. J. Bailin et al., “Lack of a hypotensive effect with rapid administration of a new aqueous formulation of intravenous amiodarone,” American Journal of Cardiology, vol. 93, no. 5, pp. 576–581, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  39. E. F. Paiva, M. B. Perondi, K. B. Kern et al., “Effect of amiodarone on haemodynamics during cardiopulmonary resuscitation in a canine model of resistant ventricular fibrillation,” Resuscitation, vol. 58, no. 2, pp. 203–208, 2003. View at Publisher · View at Google Scholar · View at Scopus
  40. P. J. Kudenchuk, L. A. Cobb, M. K. Copass et al., “Amiodarone for resuscitation after out-of-hospital cardiac arrest due to ventricular fibrillation,” The New England Journal of Medicine, vol. 341, no. 12, pp. 871–878, 1999. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  41. P. Dorian, D. Cass, B. Schwartz, R. Cooper, R. Gelaznikas, and A. Barr, “Amiodarone as compared with lidocaine for shock-resistant ventricular fibrillation,” The New England Journal of Medicine, vol. 346, no. 12, pp. 884–890, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  42. M. Manz, D. Pfeiffer, W. Jung, and B. Lueritz, “Intravenous treatment with magnesium in recurrent persistent ventricular tachycardia,” New Trends in Arrhythmias, vol. 7, no. 4, pp. 437–442, 1991. View at Scopus
  43. D. Tzivoni, S. Banai, C. Schuger et al., “Treatment of torsade de pointes with magnesium sulfate,” Circulation, vol. 77, no. 2, pp. 392–397, 1988. View at Scopus
  44. M. A. Arsenian, “Magnesium and cardiovascular disease,” Progress in Cardiovascular Diseases, vol. 35, no. 4, pp. 271–310, 1993. View at Publisher · View at Google Scholar · View at Scopus
  45. J. Allegra, R. Lavery, R. Cody et al., “Magnesium sulfate in the treatment of refractory ventricular fibrillation in the prehospital setting,” Resuscitation, vol. 49, no. 3, pp. 245–249, 2001. View at Publisher · View at Google Scholar · View at Scopus
  46. M. C. Thel, A. L. Armstrong, S. E. McNulty, R. M. Califf, and C. M. O'Connor, “Randomised trial of magnesium in in-hospital cardiac arrest. Duke internal medicine housestaff,” The Lancet, vol. 350, pp. 1272–1276, 1997.
  47. D. M. Fatovich, D. A. Prentice, and G. J. Dobb, “Magnesium in cardiac arrest (the magic trial),” Resuscitation, vol. 35, no. 3, pp. 237–241, 1997. View at Publisher · View at Google Scholar · View at Scopus
  48. D. C. Brown, A. J. Lewis, and J. M. Criley, “Asystole and its treatment: the possible role of the parasympathetic nervous system in cardiac arrest,” Journal of the American College of Emergency Physicians, vol. 8, no. 11, pp. 448–452, 1979. View at Scopus
  49. G. A. Coon, J. E. Clinton, and E. Ruiz, “Use of atropine for brady asystolic prehospital cardiac arrest,” Annals of Emergency Medicine, vol. 10, no. 9, pp. 462–467, 1981. View at Scopus
  50. H. A. Stueven, D. J. Tonsfeldt, B. M. Thompson, J. Whitcomb, E. Kastenson, and C. Aprahamian, “Atropine in asystole: human studies,” Annals of Emergency Medicine, vol. 13, no. 9, part 2, pp. 815–817, 1984.
  51. J. Engdahl, A. Bang, J. Lindqvist, and J. Herlitz, “Can we define patients with no and those with some chance of survival when found in asystole out of hospital?” American Journal of Cardiology, vol. 86, no. 6, pp. 610–614, 2000. View at Publisher · View at Google Scholar · View at Scopus
  52. I. G. Stiell, G. A. Wells, B. Field et al., “Advanced cardiac life support in out-of-hospital cardiac arrest,” The New England Journal of Medicine, vol. 351, no. 7, pp. 647–656, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  53. A. J. Tortolani, D. A. Risucci, S. R. Powell, and R. Dixon, “In-hospital cardiopulmonary resuscitation during asystole. Therapeutic factors associated with 24-hour survival,” Chest, vol. 96, no. 3, pp. 622–626, 1989. View at Scopus
  54. J. H. Kay and A. Blalock, “The use of calcium chloride in the treatment of cardiac arrest in patients,” Surgery, Gynecology & Obstetrics, vol. 93, no. 1, pp. 97–102, 1951.
  55. E. E. Harrison and B. D. Amey, “The use of calcium in cardiac resuscitation,” American Journal of Emergency Medicine, vol. 1, no. 3, pp. 267–273, 1983. View at Scopus
  56. H. A. Stueven, B. Thompson, C. Aprahamian, D. J. Tonsfeldt, and E. H. Kastenson, “Lack of effectiveness of calcium chloride in refractory asystole,” Annals of Emergency Medicine, vol. 14, no. 7, pp. 630–632, 1985. View at Scopus
  57. H. A. Stueven, B. M. Thompson, C. Aprahamian, and D. J. Tonsfeldt, “Calcium chloride: reassessment of use in asystole,” Annals of Emergency Medicine, vol. 13, no. 9, pp. 820–822, 1984. View at Scopus
  58. T. Dybvik, T. Strand, and P. A. Steen, “Buffer therapy during out-of-hospital cardiopulmonary resuscitation,” Resuscitation, vol. 29, no. 2, pp. 89–95, 1995. View at Publisher · View at Google Scholar · View at Scopus
  59. T. P. Aufderheide, D. R. Martin, D. W. Olson et al., “Prehospital bicarbonate use in cardiac arrest: a 3-year experience,” American Journal of Emergency Medicine, vol. 10, no. 1, pp. 4–7, 1992. View at Publisher · View at Google Scholar · View at Scopus
  60. H. Delooz and P. J. Lewi, “Are inter-center differences in EMS-management and sodium-bicarbonate administration important of the outcome of CPR? The cerebral resuscitation study group,” Resuscitation, vol. 17, supplement, pp. S161–S172, 1989. View at Scopus
  61. B. W. Bottiger, J. Motsch, H. Bohrer et al., “Activation of blood coagulation after cardiac arrest is not balanced adequately by activation of endogenous fibrinolysis,” Circulation, vol. 92, no. 9, pp. 2572–2578, 1995. View at Scopus
  62. M. Fischer and K. A. Hossmann, “No-reflow after cardiac arrest,” Intensive Care Medicine, vol. 21, no. 2, pp. 132–141, 1995. View at Publisher · View at Google Scholar · View at Scopus
  63. F. Spohr and B. W. Bottiger, “Safety of thrombolysis during cardiopulmonary resuscitation,” Drug Safety, vol. 26, no. 6, pp. 367–379, 2003. View at Publisher · View at Google Scholar · View at Scopus
  64. P. A. Tiffany, M. Schultz, and H. Stueven, “Bolus thrombolytic infusions during CPR for patients with refractory arrest rhythms: outcome of a case series,” Annals of Emergency Medicine, vol. 31, no. 1, pp. 124–126, 1998. View at Publisher · View at Google Scholar · View at Scopus
  65. B. W. Bottiger, C. Bode, S. Kern et al., “Efficacy and safety of thrombolytic therapy after initially unsuccessful cardiopulmonary resuscitation: a prospective clinical trial,” The Lancet, vol. 357, no. 9268, pp. 1583–1585, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  66. I. Kurkciyan, G. Meron, F. Sterz et al., “Pulmonary embolism as cause of cardiac arrest: presentation and outcome,” Archives of Internal Medicine, vol. 160, no. 10, pp. 1529–1535, 2000. View at Scopus
  67. K. Janata, M. Holzer, I. Kurkciyan et al., “Major bleeding complications in cardiopulmonary resuscitation: the place of thrombolytic therapy in cardiac arrest due to massive pulmonary embolism,” Resuscitation, vol. 57, no. 1, pp. 49–55, 2003. View at Publisher · View at Google Scholar · View at Scopus
  68. W. Lederer, C. Lichtenberger, C. Pechlaner, G. Kroesen, and M. Baubin, “Recombinant tissue plasminogen activator during cardiopulmonary resuscitation in 108 patients with out-of-hospital cardiac arrest,” Resuscitation, vol. 50, no. 1, pp. 71–76, 2001. View at Publisher · View at Google Scholar · View at Scopus
  69. W. P. Bozeman, D. M. Kleiner, and K. L. Ferguson, “Empiric tenecteplase is associated with increased return of spontaneous circulation and short term survival in cardiac arrest patients unresponsive to standard interventions,” Resuscitation, vol. 69, no. 3, pp. 399–406, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  70. K. H. Stadlbauer, A. C. Krismer, H. R. Arntz et al., “Effects of thrombolysis during out-of-hospital cardiopulmonary resuscitation,” American Journal of Cardiology, vol. 97, no. 3, pp. 305–308, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  71. D. M. Fatovich, G. J. Dobb, and R. A. Clugston, “A pilot randomised trial of thrombolysis in cardiac arrest (The TICA trial),” Resuscitation, vol. 61, no. 3, pp. 309–313, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  72. J. Gramann, P. Lange Braun, T. Bodemann, et al., “Use of thrombolytics during resuscitation as a therapy of last resort in cardiac arrest,” Intensiv-und Notfallbehandlung, vol. 16, pp. 134–137, 1991 (German).
  73. R. B. Abu-Laban, J. M. Christenson, G. D. Innes et al., “Tissue plasminogen activator in cardiac arrest with pulseless electrical activity,” The New England Journal of Medicine, vol. 346, no. 20, pp. 1522–1528, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  74. B. W. Bottiger, H. R. Arntz, D. A. Chamberlain et al., “Thrombolysis during resuscitation for out-of-hospital cardiac arrest,” The New England Journal of Medicine, vol. 359, no. 25, pp. 2651–2662, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  75. B. W. Bottiger and E. Martin, “Thrombolytic therapy during cardiopulmonary resuscitation and the role of coagulation activation after cardiac arrest,” Current Opinion in Critical Care, vol. 7, no. 3, pp. 176–183, 2001. View at Publisher · View at Google Scholar · View at Scopus
  76. C. Adrie, M. Adib-Conquy, I. Laurent et al., “Successful cardiopulmonary resuscitation after cardiac arrest as a “sepsis-like” syndrome,” Circulation, vol. 106, no. 5, pp. 562–568, 2002. View at Publisher · View at Google Scholar · View at Scopus
  77. G. Hekimian, T. Baugnon, M. Thuong et al., “Cortisol levels and adrenal reserve after successful cardiac arrest resuscitation,” Shock, vol. 22, no. 2, pp. 116–119, 2004. View at Publisher · View at Google Scholar · View at Scopus
  78. V. A. Negovsky, “The second step in resuscitation: the treatment of the “postresuscitation disease”,” Resuscitation, vol. 1, no. 1, pp. 1–7, 1972. View at Scopus
  79. D. Annane, E. Bellissant, V. Sebille, et al., “Impaired pressor sensitivity to noradrenaline in septic shock patients with and without impaired adrenal function reserve,” British Journal of Clinical Pharmacology, vol. 46, pp. 589–597, 1998.
  80. H. Prigent, V. Maxime, and D. Annane, “Clinical review: corticotherapy in sepsis,” Critical Care, vol. 8, no. 2, pp. 122–129, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  81. P. E. Marik and G. P. Zaloga, “Adrenal insufficiency in the critically III: a new look at an old problem,” Chest, vol. 122, no. 5, pp. 1784–1796, 2002. View at Publisher · View at Google Scholar · View at Scopus
  82. T. Ito, D. Saitoh, A. Takasu, T. Kiyozumi, T. Sakamoto, and Y. Okada, “Serum cortisol as a predictive marker of the outcome in patients resuscitated after cardiopulmonary arrest,” Resuscitation, vol. 62, no. 1, pp. 55–60, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  83. C. H. Schultz, E. P. Rivers, C. S. Feldkamp et al., “A characterization of hypothalamic-pituitary-adrenal axis function during and after human cardiac arrest,” Critical Care Medicine, vol. 21, no. 9, pp. 1339–1347, 1993. View at Scopus
  84. K. H. Lindner, H. U. Strohmenger, H. Ensinger, W. D. Hetzel, F. W. Ahnefeld, and M. Georgieff, “Stress hormone response during and after cardiopulmonary resuscitation,” Anesthesiology, vol. 77, no. 4, pp. 662–668, 1992. View at Publisher · View at Google Scholar · View at Scopus
  85. M. Tsai, C. Huang, W. Chang et al., “The effect of hydrocortisone on the outcome of out-of-hospital cardiac arrest patients: a pilot study,” American Journal of Emergency Medicine, vol. 25, no. 3, pp. 318–325, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus