Abstract
Objective. Most patients of acute ischemic stroke (AIS) receive treatments in the department of emergency in China. We aimed to examine the status of AIS diagnosis and treatment and the impact of green pathway operation in different regions of China. Methods. In this nationwide survey, information regarding the emergency care of AIS was collected from 451 hospitals in different regions of China, by interviewing 484 physicians from these hospitals. Structured questionnaire was used to explore the status of AIS care and impact of the green pathway. Results. 445 hospitals from 18 provinces, 4 municipalities, and 3 ethnic autonomous regions in China were included in the present study. Overall, the proportion of door-to-needle time (DNT) less than 60 min was 66.08% in the enrolled hospitals (n = 298). Stratified by regions, the results suggested that hospitals located in East regions had shorter DNT time (), and more proportion of rtPA () than those in West regions. Further analysis suggested that hospitals with a green channel were more likely to shorten DNT and improve the proportion of rtPA (). Conclusion. Considerable regional differences were observed in terms of DNT time and thrombolysis rates in the departments of emergency in China. Further studies are required to confirm the regional differences in AIS care in China.
1. Introduction
Approximately 15 million people suffered from stroke attack every year globally, with about 5 million deaths [1]. It is estimated that >7 million Chinese have strokes, and approximately 80% of them are acute ischemic stroke (AIS) by Chinese National Stroke Registry (CNSR) [2]. Rising incidence and morbidity of ischemic stroke have created a heavy economic burden to the Chinese healthcare system [3, 4].
Thrombolysis with recombinant tissue-type plasminogen activator (rtPA) is the only FDA-approved therapy for AIS [5–7] and recommended by most guidelines [8, 9]. However, it has a narrow therapeutic time window of 3 to 4.5 hours after AIS onset [10]. With the reported rate of using rtPA between 4 and 10% in the United States [11–13] and only 2% in China [2], many barriers of giving rtPA have been identified, including prehospital or in-hospital delay, short treatment time window, and lack of hospital infrastructure.
Recently, there have been several efforts to reduce in-hospital time delays, including reorganization of the Emergency Department (ED) [14], use of point-of-care international normalized ratio testing [15], acute stroke pathway [16], and establishment of green pathways for stroke thrombolysis [17] in China. However, the lack of effective supervision and continuous optimization of work flow remain the major obstacles to make significant breakthroughs in reducing in-hospital delays.
Given that most patients of stroke receive treatments in the department of emergency in China, more efforts need to be made to study the status of AIS diagnosis and treatment in emergency rooms in China, as to find out the factors related to the time required for rtPA, with a target benchmark DNT for rtPA administration less than 60 min [18, 19]. For this purpose, the present study aims to examine the current status of management of AIS in emergency departments through an online questionnaire in different regions of China.
2. Materials and Methods
2.1. Study Design
In this nationwide survey, information regarding the emergency care of AIS was collected from 451 hospitals in different regions of China, by interviewing 484 physicians from these hospitals. These physicians were selected from the hospitals registered by the National Emergency Medical Association and asked to complete a questionnaire online. The areas are divided into three major blocks, including East, Middle, and West regions, which are mainly based on the geographical location and economic development levels. The East region includes 11 provinces, municipalities, or autonomous regions, namely, Liaoning, Beijing, Tianjin, Shandong, Jiangsu, Shanghai, Zhejiang, Fujian, Guangdong, Guangxi, and Hainan. The Middle region includes Shanxi, Inner Mongolia, Jilin, Heilongjiang, Anhui, Jiangxi, Henan, Hubei, and Hunan. The West region refers to Shanxi, Gansu, Qinghai, Ningxia, Xinjiang, Sichuan, Chongqing, Yunnan, Guizhou, and Tibet. In particular, these physicians were subjected to an online questionnaire with 19 items including AIS emergency treatment, referral, proportion of rtPA, and so on (Supplementary Materials 1). The study was approved by the Ethics Committee of Beijing Tiantan Hospital, and the need for informed consent was waived.
2.2. Green Pathway
By integrating various treatment pathways in the department of emergency, neurology, neurosurgery, pharmacy, laboratory, and radiology, a green pathway for the management of AIS patients was established in some Chinese hospitals. Briefly, the ED physicians are expected to examine the suspected stroke patients immediately as the patients arrived at ED. When a patient had at least 1 warning sign of AIS, the ED physician should activate the green pathway by stamping with the seal of “Green Pathway.” Once the prescription is received, the pharmacists make it a priority to dispense the medicines promptly and the radiologists make the CT scanner ready for the patient. Consequently, the green pathway saved a considerable amount of valuable time that would have been spent in payments, obtaining medicines, waiting to be examined, and waiting for results.
2.3. Statistical Analysis
Proportions were used for descriptive analysis. Comparisons between two groups were made using Student’s tests or chi-square tests or Fisher’s exact tests. For all analysis, a 2-tailed probability value of 0.05 was considered significant and analyses were performed using R 3.1.0.
3. Results
3.1. Characteristics of Enrolled Hospitals
Apart from 6 hospitals with missing data, a total of 445 hospitals from 18 provinces, 4 municipalities, and 3 ethnic autonomous regions in China were included in the present study. Among these hospitals, 55, 40, 40, 38, 34, 34, 26, 25, and 23 of them are located in Hebei (12.36%), Hunan (8.99%), Xinjiang (8.99%), Shandong (8.54%), Chongqing (7.64%), Guangdong (7.64%), Guizhou (5.84%), Jiangsu (5.62%), and Zhejiang (5.17%), respectively, with the numbers of hospitals above 20. Nine regions with numbers of included hospitals under 10 were Fujian (0.22%), Hubei (0.22%), Jiangxi (0.22%), Ningxia (0.22%), Tianjin (0.22%), Shanxi (0.22%), Yunnan (1.80%), Henan (0.66%), and Shaanxi (1.98%) (Figure 1).
As shown in Table 1, 63.41% of the hospitals were Grade Three hospitals. 74.72% had more than 7 physicians, and 55.43% of the hospitals had a daily medical attendance more than 500 patients in the department of emergency. Of the interviewed 484 physicians from these 451 hospitals, 140 (28.9%) were chief physicians and 208 (42.9%) were associate chief physicians.
3.2. Regional Difference of AIS Treatment
During the data collection period, there are 217 hospitals with the highest proportion (48.12%) that the onset-to-needle time (ONT) was less than 4.5 hours. The proportion of DNT less than 60 min was 66.08% (n = 298), while the DNT more than 60 min was 33.92%.
There are 51.69%, 18.88%, and 29.44% of hospitals located in the East, Middle, and West regions of China, respectively. Stratified by regions, the results suggested that hospitals located in East regions had shorter DNT time () and more proportion of rtPA () than those in West regions (Table 2). In addition, the proportion of hospitals with green pathway was highest in East regions (90%), while the proportion was lower in Middle and West (77.38% and 85.50%, ).
3.3. Impact of Green Channel on AIS Treatment
In the present study, up to 86.03% (n = 388) of hospitals have established the green channel. To further study the impact of green channel on stroke treatment, we analyzed the information according to with or without green channel. As shown in Table 3, hospitals with the green channel were more likely to have shorten DNT time () and improve the proportion of rtPA treatment (, Table 3).
3.4. Impact of Green Channel on AIS Treatment in Different Blocks
To further study whether the impact of green channel on stroke treatment is different among the three blocks (East, Middle, and West), we next carried out the subgroup analysis. As shown in Table 4, we found that the DNT time is shorter in hospitals with green pathway in any area, but the difference is more pronounced in the Middle (East: ; Middle: ; West: ). Besides, the influence of green pathway on the proportion of rtPA is similar in different blocks, with significance in East and Middle areas (East: ; Middle: ; West: ).
4. Discussion
In the present study, we provide a comprehensive map of the current status of AIS treatment in emergency departments across China by using an online questionnaire, revealing large regional differences in AIS care in China. We also presented that implementation of green pathway greatly improved the time from arrival to thrombolysis, which eliminated one of the important barriers to eligibility for rtPA. In our analysis, implementation of green pathway could significantly increase the rate of rtPA by reducing in-hospital delay.
A patient with typical ischemic stroke loses nearly 1.9 million neuronal cells per minute delay of thrombolysis, which highlights the importance of a quick therapeutic approach during AIS [20]. Early reports of rtPA in routine clinical practice have demonstrated average DNTs being reduced from 100 to 48 minutes, with improvement over time suggesting a learning curve [21–23]. Despite this, only a 1.5% thrombolysis rate was observed for all AIS patients during the period of 2006 to 2008 conducted by a multihospital survey in Taiwan [24]. Recently, great successes have been achieved through multiple approaches like the reorganization of the emergency room [14], the introduction of an acute stroke team [25], a stroke code protocol [26], and green pathway. Prior to use of the green pathway, patients had to wait for the diagnosis by neurologists, the approvement of CT request, and so on. The green pathway eliminated many of those steps by strengthening the cooperation of emergency, clinical laboratory, and stroke team so that suspected stroke patients could receive treatment quickly. In our study, green pathway usage in hospitals significantly shortens DNT, with 13.14% and 56.44% of hospitals reaching the DNT goal of ≤30 and ≤60 min, respectively. Green channel is not applied for AIS only in China. As acute myocardial infarction (AMI) is a severe type of heart disease with golden hour similar with ischemic stroke, many hospitals have established the green channel for AMI to achieve timely thrombolysis within golden hours in China.
Considerable regional differences were observed in terms of DNT time and thrombolysis rates. However, it could not be explained by the regional differences in scales of hospitals, as no differences were observed regarding the daily medical attendance and numbers of physicians in the emergency departments of included hospitals from different areas of China. Besides, the hospitals included for the survey were all registered public hospitals in the National Emergency Medical Association of China. Therefore, the levels, the mass, and the operation model of these hospitals were roughly similar to each other. Interestingly, more hospitals in the east area of China have established the green pathway, which might improve the quality of AIS care significantly. In addition, lacking the knowledge of AIS treatment and thrombolysis approach, the poor economic condition and poor transportation facilities may contribute to the low rate of rtPA in the West of China.
Our study has several limitations. First, we do not have comprehensive data dividing the reason of those AIS patients who were not treated with rtPA from in-hospital or prehospital delays. A recent review revealed that about half of stroke patients have arrived hospitals within 4 hours over the last 10 years [27]. Second, we do not know whether the green pathway actually shortened DNT. Lacking a control group, our data do not provide answers to this question. Third, the present survey was conducted based on the mobile and social network based-interview, but not direct raw data of AIS care from the enrolled hospitals. In addition, analysis bias might also be induced because of the imbalance of included hospitals.
5. Conclusion
Our study provided evidence in real-world practice of AIS care in the emergency departments of China and provided new insights into the association between regional differences, economic development, and medical quality in China. Further studies are required to confirm the roles of green pathway and regional differences in AIS care in China.
Data Availability
The data used to support the findings of this study are included within the article.
Disclosure
The study has been presented at the 22nd National Emergency Medicine Annual Conference of the Chinese Medical Association Emergency Medicine Branch.
Conflicts of Interest
The authors declare that they have no conflicts of interest.
Acknowledgments
This study was supported by the Stroke Group, Emergency Medicine Branch of the Chinese Medical Association: Peng Peng, Wei Guo, Hai Kang, Jun Zhang, Xincai Ji, Chao Lan, Yunxia Zhang, Zhenying Chen, Qiang Zan, Guangjun Meng, Yingjie Li, Xi He, Xuemei Zong, Jingyu Li, Yu Zhang, Weibo Gao, Qiang Zhao, Wenqiang Jiang, Yecheng Liu, Feng Li, Hongyu Zhao, Junyi Niu, Guiyun Li, Tao Xu, Yongsheng Han, Li Li, Min Deng, Wei Gu, Dongfeng Guo, Zhigang Yu, Guoping Wu, Jining Liu, Jianzhong Yang, Chongyang Zhang, Lida Zhi, Hongsheng Liu, Ning Ding, Bin Gu, Qinzhong Zhu, Wangxiang Jiang, and Yun Li.
Supplementary Materials
Questionnaire for the emergency care of AIS in China. (Supplementary Materials)