Therapeutic Implications of Targeting AKT Signaling in Melanoma

Figure 4

Schematic representation of Akt kinases (EC number: 2.7.11.1). Akt, also known as protein kinase B, is a serine, threonine protein kinase implicated in the development and chemotherapeutic resistance of cancers. Although the three isoforms, Akt1, Akt2, and Akt3, share high degree of structural homology in terms or domain (PH, catalytic, and regulatory) architecture, they exhibit variations in some of the key amino acid residues and cellular functions. Domain organization and key phosphorylation site are represented.