Therapeutic Implications of Targeting AKT Signaling in Melanoma
Figure 8
Akt3 and downstream PRAS40 are the key regulators of melanoma cell survival. SiRNA-mediated downregulation of Akt3 and PRAS40 induced apoptosis in subcutaneous melanoma tumors. Shown are the representative pictures of TUNEL assay performed on size- and time-matched tumors. The bar graph shows the percentage TUNEL positive cells in the tumors [21].
