Research Article
Specific and Nonhomologous Isofunctional Enzymes of the Genetic Information Processing Pathways as Potential Therapeutical Targets for Tritryps
Table 2
List of additional ECs found in each process from GIPPs.
| Pathway number | Map description | T. cruzi | T. brucei | L. major | EC description |
| Translation | | | | | |
| Map00970 | Aminoacyl-tRNA biosynthesis | 2.1.2.9 | a | b | Methionyl-tRNA formyltransferase | 6.1.1.- | 6.1.1.- | 6.1.1.- | O-phosphoseryl-tRNA synthetase |
| Replication and repair | | | | | |
| Map03030 | DNA replication | 3.6.1.- | 3.6.1.- | 3.6.1.- | Hydrolases acting in phosphorus-containing anhydrides |
| Map03410 | Base excision repair | 3.1.-.- | 3.1.-.- | 3.1.-.- | Hydrolases acting on ester bonds | 3.1.11.2 | 3.1.11.2 | 3.1.11.2 | Exodeoxyribonuclease III |
| Map03420 | Nucleotide excision repair | 2.7.11.22 | 2.7.11.22 | 2.7.11.22 | Cyclin-dependent kinase |
| Map03430 | Mismatch repair | 3.6.1.- | 3.6.1.- | 3.6.1.- | Hydrolases acting in phosphorus-containing anhydrides |
| Map03440 | Homologous recombination | 3.1.-.- | 3.1.-.- | 3.1.-.- | Hydrolases acting on ester bonds |
| Map03450 | Nonhomologous end-joining | 2.7.11.1 | 2.7.11.1 | 2.7.11.1 | Nonspecific serine/threonine protein kinase | 2.7.7.7 | 2.7.7.7 | 2.7.7.7 | DNA-directed DNA polymerase | 3.1.-.- | 3.1.-.- | 3.1.-.- | Hydrolases acting on ester bonds | 4.2.99.- | 4.2.99.- | 4.2.99.- | Other carbon-oxygen lyases |
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Previously identified by KEGG as entry “Tb11.01.7110”. Previously identified by KEGG as entry “LmjF32.2240”.
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