Specific and Nonhomologous Isofunctional Enzymes of the Genetic Information Processing Pathways as Potential Therapeutical Targets for Tritryps

Table 2

List of additional ECs found in each process from GIPPs.

Pathway number	Map description	T. cruzi	T. brucei	L. major	EC description
Translation
Map00970	Aminoacyl-tRNA biosynthesis	2.1.2.9	a	b	Methionyl-tRNA formyltransferase
		6.1.1.-	6.1.1.-	6.1.1.-	O-phosphoseryl-tRNA synthetase
Replication and repair
Map03030	DNA replication	3.6.1.-	3.6.1.-	3.6.1.-	Hydrolases acting in phosphorus-containing anhydrides
Map03410	Base excision repair	3.1.-.-	3.1.-.-	3.1.-.-	Hydrolases acting on ester bonds
		3.1.11.2	3.1.11.2	3.1.11.2	Exodeoxyribonuclease III
Map03420	Nucleotide excision repair	2.7.11.22	2.7.11.22	2.7.11.22	Cyclin-dependent kinase
Map03430	Mismatch repair	3.6.1.-	3.6.1.-	3.6.1.-	Hydrolases acting in phosphorus-containing anhydrides
Map03440	Homologous recombination	3.1.-.-	3.1.-.-	3.1.-.-	Hydrolases acting on ester bonds
Map03450	Nonhomologous end-joining	2.7.11.1	2.7.11.1	2.7.11.1	Nonspecific serine/threonine protein kinase
		2.7.7.7	2.7.7.7	2.7.7.7	DNA-directed DNA polymerase
		3.1.-.-	3.1.-.-	3.1.-.-	Hydrolases acting on ester bonds
		4.2.99.-	4.2.99.-	4.2.99.-	Other carbon-oxygen lyases

aPreviously identified by KEGG as entry “Tb11.01.7110”.
bPreviously identified by KEGG as entry “LmjF32.2240”.