Role of Heme and Heme-Proteins in Trypanosomatid Essential Metabolic Pathways

Table 1

Cytochrome genes present in L. major, T.cruzi and T. brucei. Most of the genes were annotated by similarity in Gene Bank and were published within the TriTryp Genome Project. Only a few of them have been submitted to cloning and characterization.

Type of cytochromes	Organism	Genes	References
Cytb5	L. major	LmjF11.0580, LmjF09.1490, LmjF36.4675, LmjF07.0810, LmjF09.1500 (pseudogene)	Ivens [34]
	T. brucei	Tb927.3.3470, Tb927.7.520, Tb11.02.4485,Tb11.01.5225	Berriman et al. [26]
	T. cruzi	Tc00.1047053504431.109, Tc00.1047053508799.160, Tc00.1047053506773.44, Tc00.1047053507951.154, Tc00.1047053503653.60, Tc00.1047053510355.269, Tc00.1047053509395.100, Tc00.1047053506753.110	El-Sayed et al. [27]
Cytc	L. major	LmjF16.1320, LmjF16.1310	Ivens [34]
	T. brucei	Tb927.8.1890, Tb927.8.5120	Berriman et al. [26]
	T. cruzi	Tc00.1047053511391.160, Tc00.1047053508959.4, Tc00.1047053506949.50	El-Sayed et al. [27]
CytP450	L. major	LmjF27.0090, LmjF30.3550, LmjF34.3330LmjF11.1100 (lanosterol 14 α demetilase, putative)	Ivens [34]
	T. brucei	Tb927.3.680, Tb11.02.4080 (lanosterol 14 α demetilase, putative)	Joubert et al. [37], Berriman et al. [26]
	T. cruzi	Tc00.1047053509719.40, Tc00.1047053509231.10, Tc00.1047053510101.50, Tc00.1047053506297.260 (lanosterol 14-alpha-demethylase, putative)	El-Sayed et al. [27] Buckner et al. [38]