Review Article

Enolase: A Key Player in the Metabolism and a Probable Virulence Factor of Trypanosomatid Parasites—Perspectives for Its Use as a Therapeutic Target

Figure 3

Close-up view of the catalytic site and neighbourhood of T. brucei enolase in complex with the inhibitor phosphonoacetohydroxomate (PAH) (PDB code 2ptz) [50]. Ligand is shown in ball and stick representation and bound metal as grey spheres. Bound water molecules near the Cys residues are shown as lime green spheres. Selected secondary structure is shown as magenta (β-strands) or pink (loops). Selected residues are shown as sticks and labeled with those discussed in the text as potentially relevant to trypanosomatid-specific drug design coloured white.
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