Acetylcholinesterase from Human Erythrocytes as a Surrogate Biomarker of Lead Induced Neurotoxicity

Table 2

Effect of lead on the activity of AChE from human erythrocytes.

S. number	Lead concentration; (mM)	Activity; (μmol/mL/min)	% AChE activity remaining
1	0.00	2.992	100.00
2	0.05	2.514	84.02
3	0.10	2.404	80.34
4	0.50	1.933	64.60
5	1.00	1.875	62.67
6	2.00	0.683	22.83

The effect of varying concentrations of lead on the activity of AChE from human erythrocytes has been determined. The enzyme assay was carried out employing 50 µg protein using the procedure as described in Materials and Methods. The enzyme without lead served as a control and was considered to have 100% activity.