Genetic Polymorphisms of Alcohol Dehydrogenase and Aldehyde Dehydrogenase: Alcohol Use and Type 2 Diabetes in Japanese Men
Table 3
Association of combined genotypes of ADH1B and ALDH2 polymorphisms with prediabetic condition and type 2 diabetes.
ADH1B
ALDH2
No.*
Crude OR (95% CI)
Adjusted OR (95% CI)†
Interaction
Prediabetic condition
His/His
Glu/Glu
200/486
1.00 (referent)
1.00 (referent)
His/His
Glu/Lys + Lys/Lys
110/363
0.74 (0.56–0.96)
0.86 (0.64–1.16)
Arg/His
Glu/Glu
140/319
1.07 (0.82–1.38)
1.03 (0.79–1.34)
Arg/His
Glu/Lys + Lys/Lys
63/237
0.65 (0.47–0.89)
0.74 (0.53–1.05)
Arg/Arg
Glu/Glu
25/55
1.10 (0.67–1.82)
1.00 (0.59–1.67)
Arg/Arg
Glu/Lys + Lys/Lys
10/42
0.58 (0.28–1.18)
0.65 (0.31–1.34)
Type 2 diabetes
His/His
Glu/Glu
98/486
1.00 (referent)
1.00 (referent)
His/His
Glu/Lys + Lys/Lys
33/363
0.45 (0.30–0.68)
0.46 (0.29–0.72)
Arg/His
Glu/Glu
65/319
1.01 (0.72–1.43)
0.99 (0.69–1.42)
Arg/His
Glu/Lys + Lys/Lys
23/237
0.48 (0.30–0.79)
0.48 (0.28–0.80)
Arg/Arg
Glu/Glu
7/55
0.63 (0.28–1.43)
0.61 (0.27–1.41)
Arg/Arg
Glu/Lys + Lys/Lys
6/42
0.71 (0.29–1.71)
0.73 (0.29–1.81)
CI: confidence interval; OR: odd ratio. Numbers of cases/controls. Adjusted for age, hospital, rank in the Self Defense Forces, body mass index, smoking, alcohol use, coffee intake, leisure-time physical activity, and parental diabetes mellitus.
