Genetic Polymorphisms of Alcohol Dehydrogenase and Aldehyde Dehydrogenase: Alcohol Use and Type 2 Diabetes in Japanese Men

Table 5

Interaction between alcohol use and ADH1B Arg47His polymorphism in relation to prediabetic condition and type 2 diabetes.

ADH1B Genotype			Alcohol intake (mL/day)			Trend
		Never use	<30	30–59	≥60
Prediabetic condition
His/His	No.*	36/141	90/242	98/245	79/202
	OR (95% CI)^†	1.00 (referent)	1.44 (0.92–2.27)	1.52 (0.97–2.37)	1.48 (0.93–2.35)	𝑃=.16
Arg/His	No.*	23/88	37/136	68/169	72/148
	OR (95% CI)^†	0.93 (0.51–1.69)	1.07 (0.63–1.81)	1.49 (0.93–2.40)	1.85 (1.15–2.98)	𝑃=.004
Arg/Arg	No.*	1/7	8/21	11/34	15/32
	OR (95% CI)^†	0.61 (0.07–5.25)	1.45 (0.58–3.60)	1.20 (0.54–2.66)	1.64 (0.78–3.44)	𝑃=.50
Trend		𝑃=.73	𝑃=.31	𝑃=.77	𝑃=.29
		Interaction 𝑃=.27
Type 2 diabetes
His/His	No.*	9/141	41/242	42/245	36/202
	OR (95% CI)^†	1:00 (referent)	2.74 (1.26–5.95)	2.56 (1.19–5.53)	2.88 (1.32–6.31)	𝑃=.04
Arg/His	No.*	9/88	27/136	22/169	25/148
	OR (95% CI)^†	1.64 (0.61–4.39)	3.29 (1.46–7.40)	2.09 (0.91–4.79)	2.46 (1.09–5.57)	𝑃=.66
Arg/Arg	No.*	2/7	3/21	4/34	3/32
	OR (95% CI)^†	5.74 (1.01–32.66)	2.63 (0.64–10.87)	1.66 (0.46–5.94)	1.23 (0.31–4.95)	𝑃=.03
Trend		𝑃=.04	𝑃=.73	𝑃=.27	𝑃=.17
		Interaction 𝑃=.03

CI: interval confidence; OR: odd ratio.
∗Numbers of cases/controls.
†Adjusted for age, hospital, rank in the Self Defense Forces, body mass index, smoking, coffee intake, leisure–time physical activity, and parental diabetes mellitus.