Epidemiology of Sepsis as a Central Feature between Microbial Source and End-Organ Infections

Call for Papers

The incidence of sepsis is increasing continuously, making mortality rate reduction through improved intensive care unit (ICU) care and new treatment modalities a pressing issue. Multiple organ failure (MOF) in sepsis is a progressive, multistep involvement of different organs: from a microbial source to end-organ infections. Although systemic inflammatory response syndrome predominates in early sepsis, the compensatory anti-inflammatory response syndrome causes immunosuppression associated with late mortality.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the conventional epidemiology, stratified by etiological agents; the epidemiology as a tool to investigate novel links between sepsis/endotoxemia and major human pathologies; the epidemiology of pathogen drug resistances as well as the diffusion of non-antimicrobial therapies in septic conditions and the evaluation of outcomes. We are particularly interested in articles describing up-to-date epidemiological aspects of the etiological agents of sepsis, based on both conventional and novel molecular diagnostic techniques. We are also interested in the contribution that novel markers would provide to the diagnosis and prognosis of sepsis and septic shock; current concepts in the treatment of sepsis and their impact on microbial resistance; the impact of novel therapy using small molecules, SiRNA, stem cells, and gene therapy strategies. Potential topics include, but are not limited to:

• Epidemiological aspects of the etiological agents of sepsis
• Bacterial, fungal and protozoan sepsis
• Anaerobic and atypical bacterial agents of sepsis
• Multiple organ failure (MOF) in sepsis as a progressive, multistep involvement of different organs: an epidemiological point of view
• Epidemiological evidences of the role of bacteremia/sepsis in the pathogenesis of cardiovascular, neurological and metabolic diseases
• Association of prevalence of human diabetes with level of blood endotoxin
• Epidemiology of coagulation dysfunctions in sepsis
• Epidemiological evidence of the role of endothelium during bacteremia by conventional and atypical lipopolysaccharide-bearing organisms
• Epidemiological aspects of nonantimicrobial therapy administered to septic patient
• Influence of pre- and postsepsis antimicrobial therapy on the epidemiology of the sepsis

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/eri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/eri/escfms/ according to the following timetable:

Lead Guest Editor

• Alfredo Focà, Department of Health Sciences, University “Magna Graecia” of Catanzaro, Campus Universitario “Salvatore Venuta”, Viale Europa, Catanzaro, Italy

Guest Editors

• Maria Carla Liberto, Department of Health Sciences, University “Magna Graecia” of Catanzaro, Campus Universitario “Salvatore Venuta”, Viale Europa, Catanzaro, Italy
• Roman Záhorec, Department of Anesthesiology and Intensive Medicine, Comenius University Medical School, Bratislava, Slovakia