Gamma Knife Radiosurgery for Mesial Temporal Lobe Epilepsy

Table 1

Trials of Gamma Knife radiosurgery for MTLE.

Study	NO. of subjects	Dose (Gy)	Volume of treatment (mL)	Minimum followup	Seizure freedom^†
Régis et al. [15]	7	25	6.25–6.9	22*	6 (86%)
Cmelak et al. [16]	1	15	n/a	12	0
Kawai et al. [17]	2	18	6.2–8.7	18	0
Srikijvilaikul et al. [18]	5	20	6.1–8.7	24	0
Régis et al. [19]	21	24	5.5–9	24	13 (62%)
Prayson and Yoder [20]	4	20	6.1–8.7	24	0
Hoggard et al. [21]	8	25	6.2 ± 0.7	24	3 (37%)
Barbaro et al. [22]			5.5–7.5	24
High dose (24 Gy)	13	24	—	—	10 (77%)
Low dose (20 Gy)	17	20	—	—	10 (59%)
Vojtěch et al. [23]			5.2–8.9	39	0
High dose (25 Gy)	6	25	—	—	0
Low dose (18–20 Gy)	8	18–20	—	—	0
Total	92				42 (46%)
High dose (≥24 Gy)	55				32 (58%)
Low dose (<24 Gy)	37				10 (27%)

*The manuscript lists both 22 and 24 months as the minimum followup [15]. Due to the discrepancy, we list the lower of the two values in this table.
^†Seizure freedom is defined as Engel Class IA.