Review Article
The “Natural” History of Medically Treated Temporal Lobe Epilepsy: What Can an Evidence-Based Approach Tell Us?
Table 1
Prospective population-based studies of sporadic and familial temporal lobe epilepsies.
| Study | Country | Setting | Sample size | Follow-up duration | Age at onset | Silent period | History of IPI | Family history | EEG | Imaging | Rate of seizure freedom | Longest remission |
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Hauser and Kurland 1975 [7] | USA | Childhood and adult onset | ? | ? | ? | ? | ? | ? | ? | ? | 41% 2-year seizure freedom | ? | Manford et al. 1992 [6] | UK | Childhood and adult onset | 43 | 3 to 7 years | Mean 40 years-old (standard deviation 20 years) | ? | 6 (14%) | ? | 38/43 (89%); abnormality 4/38 (11%) | CT (30/43; 70%); abnormality (3/30; 10%) | 49% 2-year seizure freedom | ? | Sillanpää and Schmidt 2006 [8] | Finland | Childhood onset | 43 | Median 40 years | ? | 8/43 (19%) | ? | ? | ? | ? | 53% 5-year seizure freedom | ? | Spooner et al. 2006 [5] | Australia | Childhood onset | 62 | Median 13.7 years | Median 6.4 years old | 16/62 (26%) | 17 (27%) | 13 (21%) | vEEG temporal lobe seizure (31/62 (50%) | MRI 58/62 (94%); abnormality 28/58 (48%) | 31% 2-year seizure freedom | Median seizure-free duration 10 years (range 5–15 years) | Morita et al. 2008 [9] | Brazil | Familial mesial temporal sclerosis | 64 | Mean 7.8 years | ? | ? | ? | 100% | ? | ? | 50% 2-year seizure freedom | ? |
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CT = computed tomography; EEG = electroencephalography; IPI = initial precipitating injury; MRI = magnetic resonance imaging; vEEG = video electroencephalography.
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