Table 4: Cerebral folate deficiencies.

Disorder or mechanism
Primary cerebral folate deficiencyFolate receptor FR1 defect due to autoantibodies
Folate receptor FR1 defect due to (FOLR1 gene) mutation

Disorders with secondary cerebral folate deficiencyAicardi-Goutieres syndrome
Alpers syndrome
Isolated Rett syndrome
Kearns-Sayre syndrome
Mitochondrial complex I encephalomyopathy
Valproic acid complications