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Epilepsy Research and Treatment
Volume 2013 (2013), Article ID 583531, 12 pages
http://dx.doi.org/10.1155/2013/583531
Review Article

Continuous Spikes and Waves during Sleep: Electroclinical Presentation and Suggestions for Management

1Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Harvard Medical School, Boston Children’s Hospital, Boston, MA 02115, USA
2Department of Child Neurology, Hospital Sant Joan de Déu, Universidad de Barcelona, 08950 Barcelona, Spain
3Department of Neurology, Children’s Hospital Colorado, University of Colorado, Aurora, CO 80045, USA

Received 25 March 2013; Accepted 7 July 2013

Academic Editor: Elaine Wirrell

Copyright © 2013 Iván Sánchez Fernández et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. “Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes,” Epilepsia, vol. 30, pp. 389–399, 1989.
  2. T. Loddenkemper, I. Sánchez Fernández, and J. M. Peters, “Continuous spike and waves during sleep and electrical status epilepticus in sleep,” Journal of Clinical Neurophysiology, vol. 28, pp. 154–164, 2011.
  3. K. Nickels and E. Wirrell, “Electrical Status Epilepticus in Sleep,” Seminars in Pediatric Neurology, vol. 15, no. 2, pp. 50–60, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. I. Sánchez Fernández, T. Loddenkemper, J. M. Peters, and S. V. Kothare, “Electrical status epilepticus in sleep: clinical presentation and pathophysiology,” Pediatric Neurology, vol. 47, pp. 390–410, 2012.
  5. C. A. Tassinari, G. Cantalupo, B. Dalla Bernardina et al., “Encephalopathy related to status epilepticus during slow sleep (ESES) including Landau-Kleffner syndrome,” in Epileptic Syndromes in Infancy, Childhood and Adolescence, M. Bureau, P. Genton, C. Dravet et al., Eds., pp. 255–275, John Libbey Eurotext, London, UK, 5th edition, 2012.
  6. C. A. Tassinari, G. Rubboli, L. Volpi et al., “Encephalopathy with electrical status epilepticus during slow sleep or ESES syndrome including the acquired aphasia,” Clinical Neurophysiology, vol. 111, no. 2, supplement, pp. S94–S102, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. E. Liukkonen, E. Kantola-Sorsa, R. Paetau, E. Gaily, M. Peltola, and M.-L. Granström, “Long-term outcome of 32 children with encephalopathy with status epilepticus during sleep, or ESES syndrome,” Epilepsia, vol. 51, no. 10, pp. 2023–2032, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. M. E. Peltola, E. Liukkonen, M.-L. Granström et al., “The effect of surgery in encephalopathy with electrical status epilepticus during sleep,” Epilepsia, vol. 52, no. 3, pp. 602–609, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. I. Sánchez Fernández, K. E. Chapman, J. M. Peters et al., “The tower of Babel: survey on concepts and terminology in electrical status epilepticus in sleep and continuous spikes and waves during sleep in North America,” Epilepsia, vol. 54, pp. 741–750, 2013.
  10. J. Engel Jr., “Report of the ILAE classification core group,” Epilepsia, vol. 47, no. 9, pp. 1558–1568, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. U. Kramer, Y. Nevo, M. Y. Neufeld, A. Fatal, Y. Leitner, and S. Harel, “Epidemiology of epilepsy in childhood: a cohort of 440 consecutive patients,” Pediatric Neurology, vol. 18, no. 1, pp. 46–50, 1998. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Eksioglu, E. Tas, M. Takeoka, et al., “Clinical presentation and acute treatment of electrical status epilepticus in sleep and sleep potentiated spikes,” Neurology, vol. 72, 2009.
  13. T. Morikawa, M. Seino, Y. Watanabe, M. Watanabe, and K. Yagi, “Clinical relevance of continuous spike-waves during slow wave sleep,” in Advances in Epileptology, S. Manelis, E. Bental, J. Loeber, and F. Dreifuss, Eds., pp. 359–363, Raven Press, New York, NY, USA, 1989.
  14. A. S. Harvey, J. H. Cross, S. Shinnar, and G. W. Mathern, “Defining the spectrum of international practice in pediatric epilepsy surgery patients,” Epilepsia, vol. 49, no. 1, pp. 146–155, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. T. Loddenkemper, G. Cosmo, P. Kotagal et al., “Epilepsy surgery in children with electrical status epilepticus in sleep,” Neurosurgery, vol. 64, no. 2, pp. 328–337, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Bureau, “Outstanding cases of CSWS and LKS: analysis of the data sheets provided by the participants,” in Continuous Spikes and Waves during Slow Sleep, A. Beaumanoir, M. Bureau, L. Deonna, L. Mira, and C. A. Tassinari, Eds., pp. 213–216, John Libbey, London, UK, 1995.
  17. R. H. Caraballo, L. Bongiorni, R. Cersósimo, M. Semprino, A. Espeche, and N. Fejerman, “Epileptic encephalopathy with continuous spikes and waves during sleep in children with shunted hydrocephalus: a study of nine cases,” Epilepsia, vol. 49, no. 9, pp. 1520–1527, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. A. S. Galanopoulou, A. Bojko, F. Lado, and S. L. Moshé, “The spectrum of neuropsychiatric abnormalities associated with electrical status epilepticus in sleep,” Brain and Development, vol. 22, no. 5, pp. 279–295, 2000. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Inutsuka, K. Kobayashi, M. Oka, J. Hattori, and Y. Ohtsuka, “Treatment of epilepsy with electrical status epilepticus during slow sleep and its related disorders,” Brain and Development, vol. 28, no. 5, pp. 281–286, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Van Hirtum-Das, E. A. Licht, S. Koh, J. Y. Wu, W. D. Shields, and R. Sankar, “Children with ESES: variability in the syndrome,” Epilepsy Research, vol. 70, supplement, pp. S248–S258, 2006. View at Scopus
  21. X. Yan Liu and V. Wong, “Spectrum of epileptic syndromes with electrical status epilepticus during sleep in children,” Pediatric Neurology, vol. 22, no. 5, pp. 371–379, 2000. View at Publisher · View at Google Scholar · View at Scopus
  22. X. De Tiège, S. Goldman, S. Laureys et al., “Regional cerebral glucose metabolism in epilepsies with continuous spikes and waves during sleep,” Neurology, vol. 63, no. 5, pp. 853–857, 2004. View at Scopus
  23. X. De Tiège, N. Ligot, S. Goldman, N. Poznanski, A. de Saint Martin, and P. Van Bogaert, “Metabolic evidence for remote inhibition in epilepsies with continuous spike-waves during sleep,” NeuroImage, vol. 40, no. 2, pp. 802–810, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. I. Sánchez Fernández, J. M. Peters, S. Hadjiloizou et al., “Clinical staging and electroencephalographic evolution of continuous spikes and waves during sleep,” Epilepsia, vol. 53, no. 7, pp. 1185–1195, 2012.
  25. M. Bureau, ““Continuous spikes and waves during slow sleep” (CSWS): definition of the syndrome,” in Continuous Spikes and Waves During Slow Sleep, A. Beaumanoir, M. Bureau, L. Deonna, L. Mira, and C. A. Tassinari, Eds., pp. 17–26, John Libbey, London, UK, 1995.
  26. U. Kramer, L. Sagi, H. Goldberg-Stern, N. Zelnik, A. Nissenkorn, and B. Ben-Zeev, “Clinical spectrum and medical treatment of children with electrical status epilepticus in sleep (ESES),” Epilepsia, vol. 50, no. 6, pp. 1517–1524, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. F. Guzzetta, D. Battaglia, C. Veredice et al., “Early thalamic injury associated with epilepsy and continuous spike-wave during slow sleep,” Epilepsia, vol. 46, no. 6, pp. 889–900, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Mira, B. Oxilia, and A. Van Lierde, “Cognitive assessment of children with CSWS syndrome: a critical review of data from 155 cases submitted to the Venice colloquium,” in Continuous Spikes and Waves During Slow Sleep, A. Beaumanoir, M. Bureau, L. Deonna, L. Mira, and C. A. Tassinari, Eds., pp. 229–242, John Libbey, London, UK, 1995.
  29. T. Morikawa, M. Seino, and M. Watanabe, “Long-term outcome of CSWS syndrome,” in Continuous Spikes and Waves during Slow Sleep, A. Beaumanoir, M. Bureau, L. Deonna, L. Mira, and C. A. Tassinari, Eds., pp. 27–36, John Libbey, London, UK, 1995.
  30. F. B. J. Scholtes, M. P. H. Hendriks, and W. O. Renier, “Cognitive deterioration and electrical status epilepticus during slow sleep,” Epilepsy and Behavior, vol. 6, no. 2, pp. 167–173, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Beaumanoir, “EEG data,” in Continuous Spikes and Waves during Slow Sleep, A. Beaumanoir, M. Bureau, L. Deonna, L. Mira, and C. A. Tassinari, Eds., pp. 217–223, John Libbey, London, UK, 1995.
  32. B. Dalla Bernardina, C. A. Tassinari, and C. Dravet, “Benign focal epilepsy and “electrical status epilepticus” during sleep,” Revue d'E.E.G. et de Neuro-Physiologie Clinique, vol. 8, no. 3, pp. 350–353, 1978. View at Scopus
  33. G. Laurette and G. Arfel, “Electrical “status epilepticus” during afternoon sleep,” Revue d'E.E.G. et de Neuro-Physiologie Clinique, vol. 6, no. 1, pp. 137–139, 1976. View at Scopus
  34. G. Patry, S. Lyagoubi, and C. A. Tassinari, “Subclinical “electrical status epilepticus” induced by sleep in children. A clinical and electroencephalographic study of six cases,” Archives of Neurology, vol. 24, no. 3, pp. 242–252, 1971. View at Scopus
  35. S. Saltik, D. Uluduz, O. Cokar, V. Demirbilek, and A. Dervent, “A clinical and EEG study on idiopathic partial epilepsies with evolution into ESES spectrum disorders,” Epilepsia, vol. 46, no. 4, pp. 524–533, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Aeby, N. Poznanski, D. Verheulpen, C. Wetzburger, and P. Van Bogaert, “Levetiracetam efficacy in epileptic syndromes with continuous spikes and waves during slow sleep: experience in 12 cases,” Epilepsia, vol. 46, no. 12, pp. 1937–1942, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. J. R. Hughes, “A review of the relationships between Landau-Kleffner syndrome, electrical status epilepticus during sleep, and continuous spike-waves during sleep,” Epilepsy and Behavior, vol. 20, no. 2, pp. 247–253, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. M. Siniatchkin, K. Groening, J. Moehring et al., “Neuronal networks in children with continuous spikes and waves during slow sleep,” Brain, vol. 133, no. 9, pp. 2798–2813, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. P. Veggiotti, F. Beccaria, R. Guerrini, G. Capovilla, and G. Lanzi, “Continuous spike-and-wave activity during slow-wave sleep: syndrome or EEG pattern?” Epilepsia, vol. 40, no. 11, pp. 1593–1601, 1999. View at Publisher · View at Google Scholar · View at Scopus
  40. S. H. G. Kevelam, F. E. Jansen, E. V. Binsbergen et al., “Copy number variations in patients with electrical status epilepticus in sleep,” Journal of Child Neurology, vol. 27, no. 2, pp. 178–182, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. K. Kobayashi, H. Hata, M. Oka et al., “Age-related electrical status epilepticus during sleep and epileptic negative myoclonus in DRPLA,” Neurology, vol. 66, no. 5, pp. 772–773, 2006. View at Publisher · View at Google Scholar · View at Scopus
  42. V. Chavakula, I. Sanchez Fernandez, J. M. Peters et al., “Automated quantification of spikes,” Epilepsy & Behavior, vol. 26, pp. 143–152, 2013.
  43. R. Massa, A. De Saint-Martin, E. Hirsch et al., “Landau-Kleffner syndrome: sleep EEG characteristics at onset,” Clinical Neurophysiology, vol. 111, no. 2, supplement, pp. S87–S93, 2000. View at Publisher · View at Google Scholar · View at Scopus
  44. I. Sánchez Fernández, J. Peters, M. Takeoka, et al., “Patients with electrical status epilepticus in sleep share similar clinical features regardless of their focal or generalized sleep potentiation of epileptiform activity,” Journal of Child Neurology, vol. 28, pp. 83–89, 2013.
  45. R. Guerrini, P. Genton, M. Bureau et al., “Multilobar polymicrogyria, intractable drop attack seizures, and sleep- related electrical status epilepticus,” Neurology, vol. 51, no. 2, pp. 504–512, 1998. View at Scopus
  46. Y. Ohtsuka, A. Tanaka, K. Kobayashi et al., “Childhood-onset epilepsy associated with polymicrogyria,” Brain and Development, vol. 24, no. 8, pp. 758–765, 2002. View at Publisher · View at Google Scholar · View at Scopus
  47. C. Seegmüller, T. Deonna, C. Mayor Dubois et al., “Long-term outcome after cognitive and behavioral regression in nonlesional epilepsy with continuous spike-waves during slow-wave sleep,” Epilepsia, vol. 53, pp. 1067–1076, 2012.
  48. A. P. Aldenkamp and J. Arends, “Effects of epileptiform EEG discharges on cognitive function: is the concept of “transient cognitive impairment” still valid?” Epilepsy and Behavior, vol. 5, no. 1, supplement, pp. S25–S34, 2004. View at Publisher · View at Google Scholar · View at Scopus
  49. C. A. Tassinari, G. Cantalupo, L. Rios-Pohl, E. D. Giustina, and G. Rubboli, “Encephalopathy with status epilepticus during slow sleep: “the penelope syndrome”,” Epilepsia, vol. 50, no. 7, supplement, pp. 4–8, 2009. View at Publisher · View at Google Scholar · View at Scopus
  50. G. Incorpora, P. Pavone, P. G. Smilari, P. Trifiletti, and E. Parano, “Late primary unilateral thalamic hemorrhage in infancy: report of two cases,” Neuropediatrics, vol. 30, no. 5, pp. 264–267, 1999. View at Scopus
  51. A. Kelemen, P. Barsi, Z. Gyorsok, J. Sarac, A. Szucs, and P. Halász, “Thalamic lesion and epilepsy with generalized seizures, ESES and spike-wave paroxysms—report of three cases,” Seizure, vol. 15, no. 6, pp. 454–458, 2006. View at Publisher · View at Google Scholar · View at Scopus
  52. J. P. Monteiro, E. Roulet-Perez, V. Davidoff, and T. Deonna, “Primary neonatal thalamic haemorrhage and epilepsy with continuous spike-wave during sleep: a longitudinal follow-up of a possible significant relation,” European Journal of Paediatric Neurology, vol. 5, no. 1, pp. 41–47, 2001. View at Publisher · View at Google Scholar · View at Scopus
  53. M. Buzatu, C. Bulteau, C. Altuzarra, O. Dulac, and P. Van Bogaert, “Corticosteroids as treatment of epileptic syndromes with continuous spike-waves during slow-wave sleep,” Epilepsia, vol. 50, no. 7, supplement, pp. 68–72, 2009. View at Publisher · View at Google Scholar · View at Scopus
  54. I. Sánchez Fernández, M. Takeoka, and E. Tas, “Early thalamic lesions in patients with sleep-potentiated epileptiform activity,” Neurology, vol. 78, pp. 1721–1727, 2012.
  55. A. J. Barkovich, R. Guerrini, R. I. Kuzniecky, G. D. Jackson, and W. B. Dobyns, “A developmental and genetic classification for malformations of cortical development: update 2012,” Brain, vol. 135, no. 5, pp. 1348–1369, 2012. View at Publisher · View at Google Scholar · View at Scopus
  56. M. P. Beenhakker and J. R. Huguenard, “Neurons that fire together also conspire together: is normal sleep circuitry hijacked to generate epilepsy?” Neuron, vol. 62, no. 5, pp. 612–632, 2009. View at Publisher · View at Google Scholar · View at Scopus
  57. J. T. Paz, A. S. Bryant, K. Peng et al., “A new mode of corticothalamic transmission revealed in the Gria4 -/- model of absence epilepsy,” Nature Neuroscience, vol. 14, no. 9, pp. 1167–1175, 2011. View at Publisher · View at Google Scholar · View at Scopus
  58. J. T. Paz, C. A. Christian, I. Parada, D. A. Prince, and J. R. Huguenard, “Focal cortical infarcts alter intrinsic excitability and synaptic excitation in the reticular thalamic nucleus,” Journal of Neuroscience, vol. 30, no. 15, pp. 5465–5479, 2010. View at Publisher · View at Google Scholar · View at Scopus
  59. J. T. Paz, T. J. Davidson, and E. S. Frechette, “Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury,” Nature Neuroscience, vol. 16, pp. 64–70, 2013.
  60. G. L. Holmes and P.-P. Lenck-Santini, “Role of interictal epileptiform abnormalities in cognitive impairment,” Epilepsy and Behavior, vol. 8, no. 3, pp. 504–515, 2006. View at Publisher · View at Google Scholar · View at Scopus
  61. B. K. Bölsterli, B. Schmitt, T. Bast et al., “Impaired slow wave sleep downscaling in encephalopathy with status epilepticus during sleep (ESES),” Clinical Neurophysiology, vol. 122, no. 9, pp. 1779–1787, 2011. View at Publisher · View at Google Scholar · View at Scopus
  62. S. Diekelmann and J. Born, “The memory function of sleep,” Nature Reviews Neuroscience, vol. 11, no. 2, pp. 114–126, 2010. View at Publisher · View at Google Scholar · View at Scopus
  63. E. A. Licht, R. H. Jacobsen, and D. G. Fujikawa, “Chronically impaired frontal lobe function from subclinical epileptiform discharges,” Epilepsy and Behavior, vol. 3, no. 1, pp. 96–100, 2002. View at Publisher · View at Google Scholar · View at Scopus
  64. K. Majak and A. Pitkänen, “Do seizures cause irreversible cognitive damage? Evidence from animal studies,” Epilepsy and Behavior, vol. 5, no. 1, supplement, pp. S35–S44, 2004. View at Publisher · View at Google Scholar · View at Scopus
  65. J. Nicolai, S. Ebus, D. P. L. J. J. G. Biemans et al., “The cognitive effects of interictal epileptiform EEG discharges and short nonconvulsive epileptic seizures,” Epilepsia, vol. 53, pp. 1051–1059, 2012. View at Publisher · View at Google Scholar · View at Scopus
  66. M. Atkins and M. Nikanorova, “A prospective study of levetiracetam efficacy in epileptic syndromes with continuous spikes-waves during slow sleep,” Seizure, vol. 20, no. 8, pp. 635–639, 2011. View at Publisher · View at Google Scholar · View at Scopus
  67. G. Capovilla, F. Beccaria, S. Cagdas, A. Montagnini, R. Segala, and D. Paganelli, “Efficacy of levetiracetam in pharmacoresistant continuous spikes and waves during slow sleep,” Acta Neurologica Scandinavica, vol. 110, no. 3, pp. 144–147, 2004. View at Publisher · View at Google Scholar · View at Scopus
  68. T. Hoppen, T. Sandrieser, and M. Rister, “Successful treatment of pharmacoresistent continuous spike wave activity during slow sleep with levetiracetam,” European Journal of Pediatrics, vol. 162, no. 1, pp. 59–61, 2003. View at Publisher · View at Google Scholar · View at Scopus
  69. P. G. Larsson, K. A. Bakke, H. Bjørnæs et al., “The effect of levetiracetam on focal nocturnal epileptiform activity during sleep - A placebo-controlled double-blind cross-over study,” Epilepsy and Behavior, vol. 24, pp. 44–48, 2012. View at Publisher · View at Google Scholar · View at Scopus
  70. S.-B. Wang, W.-C. Weng, P.-C. Fan, and W.-T. Lee, “Levetiracetam in continuous spike waves during slow-wave sleep syndrome,” Pediatric Neurology, vol. 39, no. 2, pp. 85–90, 2008. View at Publisher · View at Google Scholar · View at Scopus
  71. N. Bahi-Buisson, R. Savini, M. Eisermann et al., “Misleading effects of clonazepam in symptomatic electrical status epilepticus during sleep syndrome,” Pediatric Neurology, vol. 34, no. 2, pp. 146–150, 2006. View at Publisher · View at Google Scholar · View at Scopus
  72. I. Sánchez Fernández, S. Hadjiloizou, Y. Eksioglu et al., “Short-term response of sleep-potentiated spiking to high-dose diazepam in electric status epilepticus during sleep,” Pediatric Neurology, vol. 46, no. 5, pp. 312–318, 2012. View at Publisher · View at Google Scholar · View at Scopus
  73. D. Brazzo, M. C. Pera, M. Fasce, G. Papalia, U. Balottin, and P. Veggiotti, “Epileptic encephalopathies with status epilepticus during sleep: new techniques for understanding pathophysiology and therapeutic options,” Epilepsy Research and Treatment, vol. 2012, Article ID 642725, 6 pages, 2012. View at Publisher · View at Google Scholar
  74. L. Nieuwenhuis and J. Nicolai, “The pathophysiological mechanisms of cognitive and behavioral disturbances in children with Landau-Kleffner syndrome or epilepsy with continuous spike-and-waves during slow-wave sleep,” Seizure, vol. 15, no. 4, pp. 249–258, 2006. View at Publisher · View at Google Scholar · View at Scopus
  75. R. O. Robinson, G. Baird, G. Robinson, and E. Simonoff, “Landau-Kleffner syndrome: course and correlates with outcome,” Developmental Medicine and Child Neurology, vol. 43, no. 4, pp. 243–247, 2001. View at Scopus
  76. P. Giovanardi Rossi, A. Parmeggiani, A. Posar, M. C. Scaduto, S. Chiodo, and G. Vatti, “Landau-Kleffner syndrome (LKS): long-term follow-up and links with electrical status epilepticus during sleep (ESES),” Brain and Development, vol. 21, no. 2, pp. 90–98, 1999. View at Publisher · View at Google Scholar · View at Scopus
  77. D. B. Sinclair and T. J. Snyder, “Corticosteroids for the treatment of Landau-Kleffner syndrome and continuous spike-wave discharge during sleep,” Pediatric Neurology, vol. 32, no. 5, pp. 300–306, 2005. View at Publisher · View at Google Scholar · View at Scopus
  78. P. Veggiotti, M. C. Pera, F. Teutonico, D. Brazzo, U. Balottin, and C. A. Tassinari, “Therapy of encephalopathy with status epilepticus during sleep (ESES/CSWS syndrome): an update,” Epileptic Disorders, vol. 14, no. 1, pp. 1–11, 2012. View at Publisher · View at Google Scholar · View at Scopus
  79. Ç. Okuyaz, K. Aydin, K. Gücüyener, and A. Serdaroǧlu, “Treatment of electrical status epilepticus during slow-wave sleep with high-dose corticosteroid,” Pediatric Neurology, vol. 32, no. 1, pp. 64–67, 2005. View at Publisher · View at Google Scholar · View at Scopus
  80. P. G. Larsson, K. A. Bakke, H. Bjørnæs et al., “The effect of levetiracetam on focal nocturnal epileptiform activity during sleep—a placebo-controlled double-blind cross-over study,” Epilepsy and Behavior, vol. 24, pp. 44–48, 2012. View at Publisher · View at Google Scholar · View at Scopus
  81. E. Wirrell, A. W.-C. Ho, and L. Hamiwka, “Sulthiame therapy for continuous spike and wave in slow-wave sleep,” Pediatric Neurology, vol. 35, no. 3, pp. 204–208, 2006. View at Publisher · View at Google Scholar · View at Scopus
  82. A. Van Lierde, “Therapeutic data,” in Continuous Spikes and Waves during Slow Sleep, A. Beaumanoir, M. Bureau, L. Deonna, L. Mira, and C. A. Tassinari, Eds., pp. 225–227, John Libbey, London, UK, 1995.
  83. P. Lerman, “Seizures induced or aggravated by anticonvulsants,” Epilepsia, vol. 27, no. 6, pp. 706–710, 1986. View at Scopus
  84. C. Marescaux, E. Hirsch, S. Finck et al., “Landau-Kleffner syndrome: a pharmacologic study of five cases,” Epilepsia, vol. 31, no. 6, pp. 768–777, 1990. View at Scopus
  85. O. C. Snead III and L. C. Hosey, “Exacerbation of seizures in children by carbamazepine,” New England Journal of Medicine, vol. 313, no. 15, pp. 916–921, 1985. View at Scopus
  86. M. De Negri, M. G. Baglietto, F. M. Battaglia, R. Gaggero, A. Pessagno, and L. Recanati, “Treatment of electrical status epilepticus by short diazepam (DZP) cycles after DZP rectal bolus test,” Brain and Development, vol. 17, no. 5, pp. 330–333, 1995. View at Publisher · View at Google Scholar · View at Scopus
  87. I. Sánchez Fernández, J. M. Peters, S. An, et al., “Long-term response to high-dose diazepam treatment in continuous spikes and waves during sleep,” Pediatric Neurology, 2013.
  88. W. F. M. Arts, F. K. Aarsen, M. Scheltens-De Boer, and C. E. Catsman-Berrevoets, “Landau-Kleffner syndrome and CSWS syndrome: treatment with intravenous immunoglobulins,” Epilepsia, vol. 50, no. 7, pp. 55–58, 2009. View at Publisher · View at Google Scholar · View at Scopus
  89. A. Moosa, T. Loddenkemper, and E. Wyllie, “Epilepsy surgery for congenital or early lesions,” in Pediatric Epilepsy Surgery: Preoperative Assessment and Surgical Intervention, O. Cataltepe and G. Jallo, Eds., pp. 14–23, Thieme Medical Publishers, New York, NY, USA, 2010.
  90. E. Wyllie, D. K. Lachhwani, A. Gupta et al., “Successful surgery for epilepsy due to early brain lesions despite generalized EEG findings,” Neurology, vol. 69, no. 4, pp. 389–397, 2007. View at Publisher · View at Google Scholar · View at Scopus
  91. J. H. Cross and B. G. R. Neville, “The surgical treatment of Landau-Kleffner syndrome,” Epilepsia, vol. 50, no. 7, supplement, pp. 63–67, 2009. View at Publisher · View at Google Scholar · View at Scopus
  92. K. Irwin, J. Lees, C. Polkey et al., “Multiple subpial transection in Landau-Kleffner syndrome,” Developmental Medicine and Child Neurology, vol. 43, no. 4, pp. 248–252, 2001. View at Scopus
  93. D. Battaglia, P. Veggiotti, D. Lettori et al., “Functional hemispherectomy in children with epilepsy and CSWS due to unilateral early brain injury including thalamus: sudden recovery of CSWS,” Epilepsy Research, vol. 87, no. 2-3, pp. 290–298, 2009. View at Publisher · View at Google Scholar · View at Scopus
  94. W. M. Landau and F. R. Kleffner, “Syndrome of acquired aphasia with convulsive disorder in children,” Neurology, vol. 7, no. 8, pp. 523–530, 1957. View at Scopus
  95. M. N. Fayad, R. Choueiri, and M. Mikati, “Landau-kleffner syndrome: consistent response to repeated intravenous γ-globulin doses: a case report,” Epilepsia, vol. 38, no. 4, pp. 489–494, 1997. View at Publisher · View at Google Scholar · View at Scopus
  96. L. G. Lagae, J. Silberstein, P. L. Gillis, and P. J. Casaer, “Successful use of intravenous immunoglobulins in Landau-Kleffner syndrome,” Pediatric Neurology, vol. 18, no. 2, pp. 165–168, 1998. View at Publisher · View at Google Scholar · View at Scopus
  97. M. A. Mikati and R. Saab, “Successful use of intravenous immunoglobulin as initial monotherapy in Landau-Kleffner syndrome,” Epilepsia, vol. 41, no. 7, pp. 880–886, 2000. View at Scopus
  98. M. A. Mikati, R. Saab, M. N. Fayad, and R. N. Choueiri, “Efficacy of intravenous immunoglobulin in Landau-Kleffner syndrome,” Pediatric Neurology, vol. 26, no. 4, pp. 298–300, 2002. View at Publisher · View at Google Scholar · View at Scopus
  99. M. A. Mikati and A. N. Shamseddine, “Management of Landau-Kleffner syndrome,” Pediatric Drugs, vol. 7, no. 6, pp. 377–389, 2005. View at Publisher · View at Google Scholar · View at Scopus
  100. F. Morrell, W. W. Whisler, M. C. Smith et al., “Landau-Kleffner syndrome. Treatment with subpial intracortical transection,” Brain, vol. 118, no. 6, pp. 1529–1546, 1995. View at Scopus
  101. C. P. Panayiotopoulos, M. Michael, S. Sanders, T. Valeta, and M. Koutroumanidis, “Benign childhood focal epilepsies: assessment of established and newly recognized syndromes,” Brain, vol. 131, no. 9, pp. 2264–2286, 2008. View at Publisher · View at Google Scholar · View at Scopus
  102. I. Sánchez Fernández and T. Loddenkemper, “Pediatric focal epilepsy syndromes,” Journal of Clinical Neurophysiology, vol. 29, pp. 425–440, 2012.
  103. M. Koutroumanidis, “Panayiotopoulos syndrome: an important electroclinical example of benign childhood system epilepsy,” Epilepsia, vol. 48, no. 6, pp. 1044–1053, 2007. View at Publisher · View at Google Scholar · View at Scopus
  104. “Case reports,” in Continuous Spikes and Waves during Slow Wave Sleep, A. Beaumanoir, M. Bureau, L. Deonna, L. Mira, and C. A. Tassinari, Eds., pp. 169–210, John Libbey, London, UK, 1995.
  105. J. Praline, M.-A. Barthez, P. Castelnau et al., “Atypical language impairment in two siblings: relationship with electrical status epilepticus during slow wave sleep,” Journal of the Neurological Sciences, vol. 249, no. 2, pp. 166–171, 2006. View at Publisher · View at Google Scholar · View at Scopus
  106. W. M. A. Verhoeven, J. I. M. Egger, I. Feenstra, and N. de Leeuw, “A de novo 3.57 Mb microdeletion in 8q12.3q13.2 in a patient with mild intellectual disability and epilepsy,” European Journal of Medical Genetics, vol. 55, pp. 358–361, 2012. View at Publisher · View at Google Scholar · View at Scopus
  107. C. Godfraind, M. Coutelier, S. Andries et al., “Neuroserpin mutation causes electrical status epilepticus of slow-wave sleep,” Neurology, vol. 71, no. 1, pp. 64–66, 2008. View at Publisher · View at Google Scholar · View at Scopus
  108. T. Nakayama, S. Nabatame, Y. Saito et al., “8p deletion and 9p duplication in two children with electrical status epilepticus in sleep syndrome,” Seizure, vol. 21, no. 4, pp. 295–299, 2012. View at Publisher · View at Google Scholar · View at Scopus
  109. M. Broli, F. Bisulli, M. Mastrangelo et al., “Definition of the neurological phenotype associated with dup (X)(p11.22-p11.23),” Epileptic Disorders, vol. 13, no. 3, pp. 240–251, 2011. View at Publisher · View at Google Scholar · View at Scopus
  110. R. Giorda, M. C. Bonaglia, S. Beri et al., “Complex segmental duplications mediate a recurrent dup(X)(p11.22-p11.23) associated with mental retardation, speech delay, and EEG anomalies in males and females,” American Journal of Human Genetics, vol. 85, no. 3, pp. 394–400, 2009. View at Publisher · View at Google Scholar · View at Scopus
  111. H. C. Mefford, S. C. Yendle, C. Hsu et al., “Rare copy number variants are an important cause of epileptic encephalopathies,” Annals of Neurology, vol. 70, no. 6, pp. 974–985, 2011. View at Publisher · View at Google Scholar · View at Scopus
  112. C. Reutlinger, I. Helbig, B. Gawelczyk et al., “Deletions in 16p13 including GRIN2A in patients with intellectual disability, various dysmorphic features, and seizure disorders of the rolandic region,” Epilepsia, vol. 51, no. 9, pp. 1870–1873, 2010. View at Publisher · View at Google Scholar · View at Scopus