Regulation of transcriptional elongation by MAPK signalling pathways. Mpk1 and Hog1 MAPKs are key regulators of transcription in response to specific stresses. Whereas activated Mpk1 is moving from initiation to elongation complexes through its interaction with Paf1C complex, binding of Hog1 to the ORFs seems to be dependent on the 3′UTR region of the osmoresponsive gene. Association of Mpk1 with Paf1 serves as an antitermination factor by blocking recruitment of the Sen1-Nrd1-Nab3 termination complex to the cell wall stress-responsive gene. Hog1 acts as a stress-specific transcription elongation factor (TEF) and targets selectively the RSC complex to osmoinducible ORFs, which displaces nucleosomes contributing to the efficient activation of transcription.
