Copyright © 2011 Jeremy R. Shearman and Alan N. Wilton. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

1. C. Vilà, P. Savolainen, J. E. Maldonado et al., “Multiple and ancient origins of the domestic dog,” Science, vol. 276, no. 5319, pp. 1687–1689, 1997. View at Publisher · View at Google Scholar · View at Scopus
2. R. K. Wayne and E. A. Ostrander, “Origin, genetic diversity, and genome structure of the domestic dog,” BioEssays, vol. 21, no. 3, pp. 247–257, 1999. View at Publisher · View at Google Scholar · View at Scopus
3. P. Savolainen, Y. P. Zhang, J. Luo, J. Lundeberg, and T. Leitner, “Genetic evidence for an East Asian origin of domestic dogs,” Science, vol. 298, no. 5598, pp. 1610–1613, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
4. J. F. Pang, C. Kluetsch, X. J. Zou et al., “MtDNA data indicate a single origin for dogs south of yangtze river, less than 16,300 years ago, from numerous wolves,” Molecular Biology and Evolution, vol. 26, no. 12, pp. 2849–2864, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
5. M. Germonpré, M. V. Sablin, R. E. Stevens et al., “Fossil dogs and wolves from Palaeolithic sites in Belgium, the Ukraine and Russia: osteometry, ancient DNA and stable isotopes,” Journal of Archaeological Science, vol. 36, no. 2, pp. 473–490, 2009. View at Publisher · View at Google Scholar · View at Scopus
6. T. M. Anderson, B. M. vonHoldt, S. I. Candille et al., “Molecular and evolutionary history of melanism in Norths American gray wolves,” Science, vol. 323, no. 5919, pp. 1339–1343, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
7. F. Verginelli, C. Capelli, V. Coia et al., “Mitochondrial DNA from prehistoric canids highlights relationships between dogs and South-East European wolves,” Molecular Biology and Evolution, vol. 22, no. 12, pp. 2541–2551, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
8. A. R. Boyko, R. H. Boyko, C. M. Boyko et al., “Complex population structure in African village dogs and its implications for inferring dog domestication history,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 33, pp. 13903–13908, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
9. B. M. vonHoldt, J. P. Pollinger, K. E. Lohmueller et al., “Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication,” Nature, vol. 464, no. 7290, pp. 898–902, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
10. H. G. Parker, A. V. Kukekova, D. T. Akey et al., “Breed relationships facilitate fine-mapping studies: a 7.8-kb deletion cosegregates with Collie eye anomaly across multiple dog breeds,” Genome Research, vol. 17, no. 11, pp. 1562–1571, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
11. H. G. Parker, L. V. Kim, N. B. Sutter et al., “Genetic structure of the purebred domestic domestic dog,” Science, vol. 304, no. 5674, pp. 1160–1164, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
12. K. Lindblad-Toh, C. M. Wade, T. S. Mikkelsen et al., “Genome sequence, comparative analysis and haplotype structure of the domestic dog,” Nature, vol. 438, no. 7069, pp. 803–819, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
13. T. C. Spady and E. A. Ostrander, “Canine behavioral genetics: pointing out the phenotypes and herding up the genes,” American Journal of Human Genetics, vol. 82, no. 1, pp. 10–18, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
14. F. C. F. Calboli, J. Sampson, N. Fretwell, and D. J. Balding, “Population structure and inbreeding from pedigree analysis of purebred dogs,” Genetics, vol. 179, no. 1, pp. 593–601, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
15. J. D. Wall and J. K. Pritchard, “Haplotype blocks and linkage disequilibrium in the human genome,” Nature Reviews Genetics, vol. 4, no. 8, pp. 587–597, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
16. M. M. Gray, J. M. Granka, C. D. Bustamante et al., “Linkage disequilibrium and demographic history of wild and domestic canids,” Genetics, vol. 181, no. 4, pp. 1493–1505, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
17. J. M. Akey, A. L. Ruhe, D. T. Akey et al., “Tracking footprints of artificial selection in the dog genome,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 3, pp. 1160–1165, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
18. E. K. Karlsson, I. Baranowska, C. M. Wade et al., “Efficient mapping of mendelian traits in dogs through genome-wide association,” Nature Genetics, vol. 39, no. 11, pp. 1321–1328, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
19. E. Cadieu, M. W. Neff, P. Quignon et al., “Coat variation in the domestic dog is governed by variants in three genes,” Science, vol. 326, no. 5949, pp. 150–153, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
20. E. F. Kirkness, V. Bafna, A. L. Halpern et al., “The dog genome: survey sequencing and comparative analysis,” Science, vol. 301, no. 5641, pp. 1898–1903, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
21. A. K. Wong, A. L. Ruhe, B. L. Dumont et al., “A comprehensive linkage map of the dog genome,” Genetics, vol. 184, no. 2, pp. 595–605, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
22. M. L. Metzker, “Sequencing technologies—the next generation,” Nature Reviews. Genetics, vol. 11, pp. 31–46, 2009.
23. T. J. Albert, M. N. Molla, D. M. Muzny et al., “Direct selection of human genomic loci by microarray hybridization,” Nature Methods, vol. 4, no. 11, pp. 903–905, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
24. A. Gnirke, A. Melnikov, J. Maguire et al., “Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing,” Nature Biotechnology, vol. 27, no. 2, pp. 182–189, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
25. R. Tewhey, J. B. Warner, M. Nakano et al., “Microdroplet-based PCR enrichment for large-scale targeted sequencing,” Nature Biotechnology, vol. 27, no. 11, pp. 1025–1031, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
26. D. R. Sargan, “IDID: inherited diseases in dogs: web-based information for canine inherited disease genetics,” Mammalian Genome, vol. 15, no. 6, pp. 503–506, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
27. J. J. Lee, C. Larsson, W. O. Lui, A. Höög, and H. Von Euler, “A dog pedigree with familial medullary thyroid cancer,” International Journal of Oncology, vol. 29, no. 5, pp. 1173–1182, 2006. View at Scopus
28. M. Pastor, K. Chalvet-Monfray, T. Marchal et al., “Genetic and environmental risk indicators in canine non-Hodgkin's lymphomas: breed associations and geographic distribution of 608 cases diagnosed throughout France over 1 year,” Journal of Veterinary Internal Medicine, vol. 23, no. 2, pp. 301–310, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
29. P. J. Rivera, M. Melin, T. Biagi et al., “Mammary tumor development in dogs is associated with BRCA1 and BRCA2,” Cancer Research, vol. 69, no. 22, pp. 8770–8774, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
30. G. T. Selvarajah, J. Kirpensteijn, M. E. van Wolferen, N. A. S. Rao, H. Fieten, and J. A. Mol, “Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times,” Molecular Cancer, vol. 8, article 72, 2009. View at Publisher · View at Google Scholar · View at PubMed
31. J. Tang, S. Le, L. Sun et al., “Copy number abnormalities in sporadic canine colorectal cancers,” Genome Research, vol. 20, no. 3, pp. 341–350, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
32. B. A. Tamburini, S. Trapp, T. L. Phang, J. T. Schappa, L. E. Hunter, and J. F. Modiano, “Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breed,” PLoS ONE, vol. 4, no. 5, Article ID e5549, 2009. View at Publisher · View at Google Scholar · View at PubMed
33. R. Thomas, H. J. Wang, P. C. Tsai et al., “Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma,” Chromosome Research, vol. 17, no. 3, pp. 365–377, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
34. M. W. S. Martin, M. J. Stafford Johnson, and B. Celona, “Canine dilated cardiomyopathy: a retrospective study of signalment, presentation and clinical findings in 369 cases,” Journal of Small Animal Practice, vol. 50, no. 1, pp. 23–29, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
35. L. J. Gershwin, “Autoimmune diseases in small animals,” Veterinary Clinics of North America—Small Animal Practice, vol. 40, no. 3, pp. 439–457, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
36. L. Lin, J. Faraco, R. Li et al., “The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene,” Cell, vol. 98, no. 3, pp. 365–376, 1999. View at Publisher · View at Google Scholar · View at Scopus
37. M. Hungs, L. Lin, M. Okun, and E. Mignot, “Polymorphisms in the vicinity of the hypocretin/orexin are not associated with human narcolepsy,” Neurology, vol. 57, no. 10, pp. 1893–1895, 2001. View at Scopus
38. B. Zangerl, O. Goldstein, A. R. Philp et al., “Identical mutation in a novel retinal gene causes progressive rod-cone degeneration in dogs and retinitis pigmentosa in humans,” Genomics, vol. 88, no. 5, pp. 551–563, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
39. N. H. C. Salmon Hillbertz, M. Isaksson, E. K. Karlsson et al., “Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs,” Nature Genetics, vol. 39, no. 11, pp. 1318–1320, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
40. M. Wilbe, P. Jokinen, K. Truvé et al., “Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex,” Nature Genetics, vol. 42, no. 3, pp. 250–254, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
41. N. B. Sutter, D. S. Mosher, M. M. Gray, and E. A. Ostrander, “Morphometrics within dog breeds are highly reproducible and dispute rensch's rule,” Mammalian Genome, vol. 19, no. 10-12, pp. 713–723, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
42. B. D. Rodgers and D. K. Garikipati, “Clinical, agricultural, and evolutionary biology of myostatin: a comparative review,” Endocrine Reviews, vol. 29, no. 5, pp. 513–534, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
43. D. S. Mosher, P. Quignon, C. D. Bustamante et al., “A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs.,” PLoS Genetics, vol. 3, no. 5, article e79, 2007. View at Publisher · View at Google Scholar · View at PubMed
44. E. W. Hill, J. Gu, S. S. Eivers et al., “A sequence polymorphism in MSTN predicts sprinting ability and racing stamina in thoroughbred horses,” PLoS ONE, vol. 5, no. 1, Article ID e8645, 2010. View at Publisher · View at Google Scholar · View at PubMed
45. J. Topal, M. Gacsi, E. Miklosi, Z. Viranyi, E. Kubinyi, and V. Csanyi, “Attachment to humans: a comparative study on hand-reared wolves and differently socialized dog puppies,” Animal Behaviour, vol. 70, no. 6, pp. 1367–1375, 2005. View at Publisher · View at Google Scholar · View at Scopus
46. M. Gacsi, B. Gyori, E. Miklosi et al., “Species-specific differences and similarities in the behavior of hand-raised dog and wolf pups in social situations with humans,” Developmental Psychobiology, vol. 47, no. 2, pp. 111–122, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
47. M. Gácsi, B. Györi, Z. Virányi et al., “Explaining dog wolf differences in utilizing human pointing gestures: selection for synergistic shifts in the development of some social skills,” PLoS ONE, vol. 4, no. 8, Article ID e6584, 2009. View at Publisher · View at Google Scholar · View at PubMed
48. P. Jones, K. Chase, A. Martin, P. Davern, E. A. Ostrander, and K. G. Lark, “Single-nucleotide-polymorphism-based association mapping of dog stereotypes,” Genetics, vol. 179, no. 2, pp. 1033–1044, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
49. Y. Takeuchi, F. Kaneko, C. Hashizume et al., “Association analysis between canine behavioural traits and genetic polymorphisms in the Shiba Inu breed,” Animal Genetics, vol. 40, no. 5, pp. 616–622, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus