The Roles of the Paf1 Complex and Associated Histone Modifications in Regulating Gene Expression
Figure 1
The multiple functions of the Paf1C. During transcription elongation, the Paf1C (a) associates with RNA pol II on coding regions [4, 6], (b) regulates histone modifications [8–12] (discussed in detail in Figure 2), and (c) recruits Chd1, an ATP-dependent chromatin remodeling enzyme [131, 132]. (d) During a later stage of transcription elongation, the Paf1C promotes phosphorylation of serine 2 of the RNA pol II CTD [13, 31]. (e) Additionally, the Paf1C is important for proper transcription termination and RNA 3′ end formation of both polyadenylated and nonpolyadenylated transcripts [13–16, 31].
