Control of V(D)J Recombination through Transcriptional Elongation and Changes in Locus Chromatin Structure and Nuclear Organization

Figure 5

Representation of WT Tcra locus and mutant versions containing a terminator sequence [4, 5]. V, D, and J gene segments are represented as red, orange, and green rectangles, respectively. RSSs are represented as white and black triangles. Constant regions are represented as purple rectangles. Promoters, including the TEA promoter, are represented as blue diamonds, and arrows indicate transcription. Eδ and Eα are represented as red circles. The position of the terminator sequence in mutant TEA-T and 56R Tcra is indicated.