Review Article

Epigenetics in Friedreich's Ataxia: Challenges and Opportunities for Therapy

Figure 1

The position of DNA methylation and CTCF binding sites within TNR expansion loci. (a) FRAXA, (b) DM1, (c) SCA7, and (d) FRDA. Grey boxes represent regions of disease-associated DNA methylation. Arrow marks represent the direction of transcription. Red triangles indicate the position of repeats. This image was adapted from [139].
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(a) FRAXA
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(b) DM1
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(c) SCA7
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(d) FRDA