Research Article
Association Study between Idiopathic Scoliosis and Polymorphic Variants of VDR, IGF-1, and AMPD1 Genes
Table 3
Genotype and allele frequency distributions in patients (
) with idiopathic scoliosis (IS) and healthy controls (
).
| Gene,
polymorphism | Genotype,
allele | Cases
, % | Controls
, % |
| VDR
(rs2228670) | FF | 56 (53.3) | 108 (51.4) | | Ff | 43 (41.0) | 92 (43.8) | | ff | 6 (5.7) | 10 (4.8) | | F | 155 (73.8) | 308 (73.3) | | f | 55 (26.2) | 112 (26.7) |
| IGF-1
(rs5742612) | TT | 94 (89.5) | 185 (88.1) | | CT | 10 (9.5) | 21 (10.0) | | CC | 1 (1.0) | 4 (1.9) | | T | 198 (94.3) | 391 (93.1) | | C | 12 (5.7) | 29 (6.9) |
| AMPD1
(rs17602729) | CC | 73 (69.5) | 152 (72.4) | | CT | 27 (25.7) | 53 (25.2) | | TT | 5 (4.8) | 5 (2.4) | | C | 173 (82.4) | 357 (85.0) | | T | 37 (17.6) | 63 (15.0) |
|
|
All values were not significant. VDR indicates vitamin D receptor; IGF-1: insulin-like growth factor-1; AMPD1: adenosine monophosphate deaminase 1.
|
