Genetics Research International

Research Article

Association Study between Idiopathic Scoliosis and Polymorphic Variants of VDR, IGF-1, and AMPD1 Genes

Table 4

Odds ratios of genotypes and alleles in different subgroups with IS.


Subgroup	Gene	Genotype, allele	OR [95% CI]

General ()	VDR	FF versus Ff + ff F versus f	1.08 [0.68–1.73] 1.02 [0.70–1.49]
	IGF-1	TT versus CC + CT T versus C	1.15 [0.54–2.45] 1.22 [0.61–2.45]
	AMPD1	CC versus TT + CT C versus T	0.87 [0.52–1.45] 0.83 [0.53–1.29]

AIS ()	VDR	FF versus Ff + ff F versus f	1.10 [0.65–1.86] 1.02 [0.67–1.55]
	IGF-1	TT versus CC + CT T versus C	0.92 [0.42–2.01] 0.98 [0.48–2.01]
	AMPD1	CC versus TT + CT C versus T	0.86 [0.49–1.51] 0.84 [0.51–1.38]

Familial history of IS ()	VDR	FF versus Ff + ff F versus f	1.46 [0.65–3.27] 1.20 [0.62–2.32]
	IGF-1	TT versus CC + CT T versus C	1.76 [0.39–7.85] 1.31 [0.39–4.45]
	AMPD1	CC versus TT + CT C versus T	2.29 [0.76–6.88] 2.29 [0.80–6.57]

Cobb angle >40° ()	VDR	FF versus Ff + ff F versus f	0.94 [0.57–1.57] 0.96 [0.65–1.44]
	IGF-1	TT versus CC + CT T versus C	1.00 [0.46–2.18] 1.17 [0.56–2.46]
	AMPD1	CC versus TT + CT C versus T	0.76 [0.44–1.32] 0.72 [0.45–1.15]

Thoracic scoliosis ()	VDR	FF versus Ff + ff F versus f	1.50 [0.84–2.67] 1.25 [0.78–2.00]
	IGF-1	TT versus CC + CT T versus C	1.06 [0.44–2.59] 1.24 [0.53–2.90]
	AMPD1	CC versus TT + CT C versus T	1.07 [0.57–2.01] 1.03 [0.59–1.79]

Lumbar scoliosis ()	VDR	FF versus Ff + ff F versus f	1.32 [0.41–4.30] 1.09 [0.42–2.82]
	IGF-1	TT versus CC + CT T versus C	1.48 [0.31–7.15] 1.93 [0.54–6.84]
	AMPD1	CC versus TT + CT C versus T	1.91 [0.41–8.97] 1.24 [0.36–4.26]

Thoracolumbar scoliosis ()	VDR	FF versus Ff + ff F versus f	1.93 [0.88–4.22] 1.41 [0.80–2.49]
	IGF-1	TT versus CC + CT T versus C	1.96 [0.44–8.72] 2.23 [0.52–9.57]
	AMPD1	CC versus TT + CT C versus T	1.66 [0.76–3.62] 1.81 [0.95–3.43]

Males ()	VDR	FF versus Ff + ff F versus f	0.65 [0.22–1.98] 0.65 [0.27–1.60]
	IGF-1	TT versus CC + CT T versus C	0.73 [0.11–4.78] 0.65 [0.14–3.05]
	AMPD1	CC versus TT + CT C versus T	0.56 [0.18–1.77] 0.47 [0.18–1.24]

Females ()	VDR	FF versus Ff + ff F versus f	1.21 [0.72–2.03] 1.13 [0.74–1.71]
	IGF-1	TT versus CC + CT T versus C	1.25 [0.55–2.86] 1.42 [0.65–3.11]
	AMPD1	CC versus TT + CT C versus T	0.97 [0.54–1.73] 0.96 [0.58–1.58]

All values were not significant. IS indicates idiopathic scoliosis; AIS: adolescent idiopathic scoliosis; OR: odds ratio; CI: confidence interval; VDR: vitamin D receptor; IGF-1: insulin-like growth factor-1; AMPD1: adenosine monophosphate deaminase 1.