SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses, in Human Liver Diseases

Figure 1

Schematic structure of SOCS proteins. SOCS proteins are structurally characterized by a central SH2 domain, a docking motif to tyrosine-phosphorylated proteins, and a c-terminal SOCS box that recruits Elongin B/C complex. SOCS1 and SOCS3 also possess a KIR domain, which plays an important role in inhibition of JAK kinase activity. The length of N-terminal domain varies between SOCS proteins and SOCS4-7 possesses relatively long N-terminal domain.