The TLR4/TRIF-Mediated Activation of NLRP3 Inflammasome Underlies Endotoxin-Induced Liver Injury in Mice
Figure 3
Kupffer cells promptly capture heat-killed P. acnes. Cy3-labeled, heat-killed P. acnes (red) were administered into naïve wild-type mice through a tail vein, and at 3 h tissue specimens were sampled. Frozen tissue slices were incubated with anti-F4/80 mAb (green) and DAPI for detecting macrophages and cell nuclei, respectively. cells (Kupffer cells) capture P. acnes, while both and cells ingest them in the spleen. In contrast to live and spleen, both lung and kidney rarely contain P. acnes. Magnification of insets is x800.
