Reliability of Diagnostic Tests for Helicobacter pylori Infection
Table 3
Performance of different diagnostic tests for H. pylori infection. Each method is tested against culture as gold standard. RUT: rapid urease test, UBT = 13C-urea breath test, c.i.: confidence interval.
(a) Antrum and/or corpus.
Diagnostic test
Sensitivity (95% ci.)
Specificity (95% ci.)
PPV (95% ci.)
NPV (95% ci.)
Accuracy (95% ci.)
Serology
0.99 (0.93–1.00)
0.82 (0.76–0.87)
0.66 (0.56–0.74)
0.99 (0.97–1.00)
0.86 (0.82–0.90)
UBT
0.89 (0.81–0.94)
0.99 (0.97–1.00)
0.99 (0.94–1.00)
0.95 (0.91–0.97)
0.96 (0.93–0.98)
RUT
0.90 (0.83–0.95)
0.98 (0.95–0.99)
0.96 (0.90–0.99)
0.95 (0.91–0.98)
0.95 (0.92–0.97)
Histology
0.90 (0.83–0.95)
0.97 (0.94–0.99)
0.94 (0.87–0.98)
0.95 (0.91–0.98)
0.95 (0.92–0.97)
(b) Antrum. (culture failed/no growth in two subjects)
Diagnostic test
Sensitivity (95% ci.)
Specificity (95% ci.)
PPV (95% ci.)
NPV (95% ci.)
Accuracy (95% ci.)
RUT
0.91 (0.83–0.96)
0.98 (0.95–0.99)
0.95 (0.89–0.99)
0.96 (0.93–0.98)
0.96 (0.93–0.98)
Histology
0.85 (0.76–0.91)
0.96 (0.93–0.98)
0.91 (0.82–0.96)
0.94 (0.89–0.96)
0.93 (0.89–0.95)
(c) Corpus. (culture failed/no growth in one subject)
