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Gastroenterology Research and Practice
Volume 2012 (2012), Article ID 159438, 6 pages
http://dx.doi.org/10.1155/2012/159438
Clinical Study

Effect of Ursodeoxycholic Acid Alone and Ursodeoxycholic Acid Plus Domperidone on Radiolucent Gallstones and Gallbladder Contractility in Humans

1Department of Gastroenterology, Istanbul Medeniyet University, Medical Faculty, Goztepe Education and Research Hospital, Istanbul, Turkey
2Departments of Radiology, Yuzuncu Yil University Medical Faculty, Van, Turkey
3Department of Gastroenterology, Bezmiâlem Vakif University Medical Faculty, Istanbul, Turkey

Received 6 December 2011; Revised 1 February 2012; Accepted 1 February 2012

Academic Editor: Stuart Sherman

Copyright © 2012 Ilyas Tuncer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Barbara, C. Sama, A. M. M. Labate, et al., “A population study on the prevalence of gallstone disease: the Sirmione study,” Hepatology, vol. 7, no. 5, pp. 913–917, 1987. View at Scopus
  2. D. E. Johnston and M. M. Kaplan, “Pathogenesis and treatment of gallstones,” The New England Journal of Medicine, vol. 328, no. 6, pp. 412–421, 1993. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Di Ciaula, D. Q. H. Wang, H. H. Wang, L. Bonfrate, and P. Portincasa, “Targets for current pharmacologic therapy in cholesterol gallstone disease,” Gastroenterology Clinics of North America, vol. 39, no. 2, pp. 245–264, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. R. K. Sterling and M. L. Shiffman, “Nonsteroidal antiinflammatory drugs and gallstone disease: will an aspirin a day keep the gallstones away?” American Journal of Gastroenterology, vol. 93, no. 9, pp. 1405–1407, 1998. View at Publisher · View at Google Scholar · View at Scopus
  5. H. H. Wang, P. Portincasa, N. Mendez-Sanchez, M. Uribe, and D. Q. H. Wang, “Effect of ezetimibe on the prevention and dissolution of cholesterol gallstones,” Gastroenterology, vol. 134, no. 7, pp. 2101–2110, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. H. H. Wang, P. Portincasa, N. Mendez-Sanchez, M. Uribe, and D. Q. Wang, “Medicinal treatments of cholesterol gallstones: old, current and new perspectives,” Current Medicinal Chemistry, vol. 16, no. 12, pp. 1531–1542, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. F. M. Konikoff, “Gallstones—approach to medical management,” MedGenMed, vol. 5, no. 4, article 8, 2003. View at Scopus
  8. T. Sauerbruch and M. Neubrand, “Nonsurgical management of gallstones,” Progress in liver diseases, vol. 10, pp. 193–218, 1992.
  9. R. A. Rubin, T. E. Kowalski, M. Khandelwal, and P. F. Malet, “Ursodiol for hepatobiliary disorders,” Annals of Internal Medicine, vol. 121, no. 3, pp. 207–218, 1994. View at Scopus
  10. M. C. Bateson, “Fortnightly review: gallbladder disease,” British Medical Journal, vol. 318, no. 7200, pp. 1745–1748, 1999. View at Scopus
  11. P. Portincasa, P. van de Meeberg, K. J. van Erpecum, G. Palasciano, and G. P. VanBerge-Henegouwen, “An update on the pathogenesisi and treatment of cholesterol stones,” Scandinavian Journal of Gastroenterology, vol. 223, pp. 60–69, 1997.
  12. E. Tankurt, S. Apaydin, E. Ellidokuz et al., “The prokinetic effect of domperidone in gallbladder - not upon dopaminergic receptors,” Pharmacological Research, vol. 34, no. 3-4, pp. 153–156, 1996. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Mangiameli, A. Brogna, R. Catanzaro, M. Sofia, and A. Blasi, “Levosulpiride vs domperidone for functional dyspepsia,” Clinica Terapeutica, vol. 144, no. 2, pp. 107–114, 1994. View at Scopus
  14. M. C. Champion, M. Hartnett, and M. Yen, “Domperidone, a new dopamine antagonist,” Canadian Medical Association Journal, vol. 135, no. 5, pp. 457–461, 1986. View at Scopus
  15. F. E. Murray, S. J. Stinchcombe, and C. J. Hawkey, “Effect of indomethacin and misoprostol on fasted gallbladder volume and meal-induced gallbladder contractility in humans,” Digestive Diseases and Sciences, vol. 37, no. 8, pp. 1228–1231, 1992. View at Scopus
  16. G. Paumgartner, “Nonsugical management of gallstone disease,” in Gastrointestinal and Liver Disease, M. Feldman, L. S. Friedman, and M. H. Sleisenger, Eds., pp. 1107–1115, Elsevier Saunders, Philadelphia, Pa, USA, 7th edition, 2002.
  17. I. Hirota, K. Chijiiwa, H. Noshiro, and F. Nakayama, “Effect of chenodeoxycholate and ursodeoxycholate on nucleation time in human gallbladder bile,” Gastroenterology, vol. 102, no. 5, pp. 1668–1674, 1992. View at Scopus
  18. M. Angelico, “The medical therapy of cholelithiasis. Critical reflections,” Annali Italiani di Chirurgia, vol. 69, no. 6, pp. 709–711, 1998. View at Scopus
  19. K. A. Hood, D. C. Ruppin, and R. H. Dowling, “Gall stone recurrence and its prevention: the British/Belgian gall stone study group's post-dissolution trial,” Gut, vol. 34, no. 9, pp. 1277–1288, 1993. View at Scopus
  20. Tokyo Cooperative Gallstone Study Group, “Efficacy and indications of ursodeoxycholic acid treatment for dissolving gallstones,” Gastroenterology, vol. 78, no. 3, pp. 542–548, 1980.
  21. G. R. May, L. R. Sutherland, and E. A. Shaffer, “Efficacy of bile acid therapy for gallstone dissolution: a meta-analysis of randomized trials,” Alimentary Pharmacology and Therapeutics, vol. 7, no. 2, pp. 139–148, 1993. View at Scopus
  22. R. P. Jazrawi, M. G. Pigozzi, G. Galatola, A. Lanzini, and T. C. Northfield, “Optimum bile acid treatment for rapid gall stone dissolution,” Gut, vol. 33, no. 3, pp. 381–386, 1992. View at Scopus
  23. L. J. Schoenfield and J. W. Marks, “Oral and contact dissolution of gallstones,” American Journal of Surgery, vol. 165, no. 4, pp. 427–430, 1993. View at Scopus
  24. F. Bazzoli, D. Festi, G. Mazzella et al., “Acquired gallstone opacification during cholelitholytic treatment with chenodeoscyholic, ursodeoxycholic, and tauroursodeoxycholic acids,” American Journal of Gastroenterology, vol. 90, no. 6, pp. 978–981, 1995. View at Scopus
  25. M. Podda, M. Zuin, N. Dioguardi, et al., “A combination of chenodeoxycholic acid and ursodeoxycholic acid is more effective than either alone in reducing biliary cholesterol saturation,” Hepatology, vol. 2, no. 3, pp. 334–339, 1982. View at Scopus
  26. M. Zuin, M. L. Petroni, G. Grandinetti et al., “Comparison of effects of chenodeoxycholic and ursodeoxycholic acid and their combination on biliary lipids in obese patients with gallstones,” Scandinavian Journal of Gastroenterology, vol. 26, no. 3, pp. 257–262, 1991.
  27. M. L. Petroni, R. P. Jazrawi, P. Pazzi et al., “Ursodeoxycholic acid alone or with chenodeoxycholic acid for dissolution of cholesterol gallstones: a randomized multicentre trial,” Alimentary Pharmacology and Therapeutics, vol. 15, no. 1, pp. 123–128, 2001. View at Publisher · View at Google Scholar
  28. S. Tazuma, G. Kajiyama, T. Mizuno et al., “A combination therapy with simvastatin and ursodeoxycholic acid is more effective for cholesterol gallstone dissolution than is ursodeoxycholic acid monotherapy,” Journal of Clinical Gastroenterology, vol. 26, no. 4, pp. 287–291, 1998. View at Publisher · View at Google Scholar · View at Scopus
  29. H. Kilbinger and T. R. Weihrauch, “Drugs increasing gastrointestinal motility,” Pharmacology, vol. 25, no. 2, pp. 61–72, 1982. View at Scopus
  30. S. Nakayama, T. Neya, and T. Yamasato, “Effects of domperidone on gastrointestinal and gallbladder motility and gastric emptying,” Nippon Heikatsukin Gakkai Zasshi, vol. 15, no. 4, pp. 327–335, 1979.
  31. S. Kapicioglu, O. Senturk, N. Bambul, and K. Ilgun, “Action of cisapride on gallbladder contraction in patients with diabetes mellitus,” Hepatogastroenterology, vol. 45, no. 23, pp. 1410–1414, 1998. View at Scopus
  32. M. Gürsoy, N. Güvener, I. Isiklar, E. Tutal, B. Ozin, and S. Boyacioglu, “The effect of cisaprid on gallbladder contractility in type II diabetic patients,” Hepatogastroenterology, vol. 48, no. 41, pp. 1262–1265, 2001. View at Scopus
  33. C. J. Sinal, M. Tohkin, M. Miyata, J. M. Ward, G. Lambert, and F. J. Gonzalez, “Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis,” Cell, vol. 102, no. 6, pp. 731–744, 2000. View at Scopus
  34. M. Montagnani, A. Marangoni, A. Roda et al., “Generation of a novel antibody probe to the apical sodium-dependent bile acid transporter that inhibits ileal bile acid absorption,” Molecular Pharmaceutics, vol. 6, no. 3, pp. 1012–1018, 2009. View at Publisher · View at Google Scholar · View at Scopus