Molecular Biologic Approach to the Diagnosis of Pancreatic Carcinoma Using Specimens Obtained by EUS-Guided Fine Needle Aspiration

Table 4

Studies of molecular biologic diagnosis of pancreatic carcinoma using specimens obtained by EUS-FNA.

Biological analyses	Author	Year	EUS-FNA samples	Sensitivity	Specificity	Positive predictive value	Negative positive value	Accuracy	Diagnosis
	Reicher et al. [11]	2011	46	87.9%	93.8%	96.7%	78.9%	89.8%	Combination with cytology and FISH
KRAS	Bournet et al. [10]	2009	178	88.0%	100%	100%	63.0%	90.0%	Combination with cytopathology
	Maluf-Filho et al. [8]	2007	74	90.9%	47.6%	89.5%	98.1%	89.2%	Combination with cytopathology
P53	Jahng et al. [17]	2010	61	51.0%	100%				Combination with cytology
	Itoi et al. [16]	2005	62	90.0%	91.0%			92%	Combination with cytopathology
P16	Salek et al. [20]	2007	101	85.0%	100.0%				Monitoring the loss of heterozygosity
SMAD4	Salek et al. [20]	2007	101	78.0%	57.0%				Monitoring the loss of heterozygosity
MUCs	Wang et al. [26]	2007	40	100%				91.1%	MUC5AC+cytology
	Giorgadze et al. [25]	2006	30	70%	100%	100%	100%	75%	Combination of MUC1+/ MUC2−/ MUC5AC+
S100P	Kosarac et al. [34]	2011	14	78.2%	87.5%
	Daniel et al. [35]	2011	62	90.0%	67.0%

*FISH: fluorescense in situ hybridization.