Table 4: Studies of molecular biologic diagnosis of pancreatic carcinoma using specimens obtained by EUS-FNA.

Biological analyses Author Year EUS-FNA samples Sensitivity Specificity Positive predictive value Negative positive value Accuracy Diagnosis   Reicher et al. [11] 2011 46 87.9% 93.8% 96.7% 78.9% 89.8% Combination with cytology and FISH KRAS Bournet et al. [10] 2009 178 88.0% 100% 100% 63.0% 90.0% Combination with cytopathology   Maluf-Filho et al. [8] 2007 74 90.9% 47.6% 89.5% 98.1% 89.2% Combination with cytopathology P53 Jahng et al. [17] 2010 61 51.0% 100%       Combination with cytology Itoi et al. [16] 2005 62 90.0% 91.0%     92% Combination with cytopathology P16 Salek et al. [20] 2007 101 85.0% 100.0%       Monitoring the loss of heterozygosity SMAD4 Salek et al. [20] 2007 101 78.0% 57.0%       Monitoring the loss of heterozygosity MUCs Wang et al. [26] 2007 40 100%       91.1% MUC5AC+cytology   Giorgadze et al. [25] 2006 30 70% 100%  100%  100% 75% Combination of MUC1+/ MUC2−/ MUC5AC+ S100P Kosarac et al. [34] 2011 14 78.2% 87.5%         Daniel et al. [35] 2011 62 90.0% 67.0%

*FISH: fluorescense in situ hybridization.